INT114879

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.33
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Anatomy Link Frequency
hepatocyte 1
BxPC-3 1
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.06 Very High Very High Very High
Inflammation 12 59.00 Quite High
antagonist 6 46.64 Quite Low
cytokine 4 37.68 Quite Low
cINOD 10 17.36 Low Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 99.36 Very High Very High Very High
Cancer 108 96.92 Very High Very High Very High
Myeloid Leukemia 1 96.68 Very High Very High Very High
Leukemia 5 96.48 Very High Very High Very High
Necrosis 3 86.80 High High
Repression 6 82.24 Quite High
Breast Cancer 6 81.60 Quite High
Targeted Disruption 9 77.68 Quite High
Apoptosis 121 77.04 Quite High
Toxicity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Gene_expression (expression) of Cdk2 in hepatocyte associated with paracetamol and hepatotoxicity
1) Confidence 0.55 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.57 Pain Relevance 0.57
As shown in Figure 7A, IGF-1 significantly upregulated CCNE1, CDK2, and CREB1 protein expression.
Gene_expression (expression) of CDK2
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.12 Pain Relevance 0
Therefore, we examined cyclin D1, E and A cdk2 activities in TM10 and TM2H cell cultures after 24 h treatment with SAHA because they reflect kinase activities before, during and after the G1 ?
Spec (examined) Gene_expression (activities) of cdk2
3) Confidence 0.28 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.08 Pain Relevance 0
nor sFasL alone or together altered the expression of cdk2 or cyclin E compared to control cultures (Figure 9).
Gene_expression (expression) of cdk2
4) Confidence 0.23 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.26 Pain Relevance 0
p27(KIP1) expression and inhibited cyclin E, cyclin D2 and CDK2 [122].
Gene_expression (expression) of CDK2
5) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.75 Pain Relevance 0
Western blot analyses indicated that [6]-gingerol decreased the expression of Cyclin A and Cdks including Cdk2, Cdk4, and Cdk6 in BxPC-3.
Gene_expression (expression) of Cdk2 in BxPC-3
6) Confidence 0.15 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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