INT114880

Context Info Confidence 0.35 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.89 Pain Relevance 0.77

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2) mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)

Anatomy Link Frequency hepatocyte 1 BxPC-3 1 Cdk2 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 11 97.30 ischemia 1 92.76 cINOD 1 71.36 Inflammation 6 70.80 Somatostatin 4 54.28 cytokine 3 38.80 fibrosis 2 20.76 antagonist 1 15.12 palliative 5 5.00 Mechanosensation 4 5.00

Disease Link Frequency Relevance Heat Skin Cancer 3 99.80 Hepatotoxicity 3 97.60 Injury 6 94.12 Cv Unclassified Under Development 9 92.76 Brain Injury 1 92.12 Convulsion 1 90.00 Disease 150 88.00 Death 28 86.40 Apoptosis 87 83.28 Necrosis 15 83.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.

Negative_regulation (reduced) of Cdk2 in hepatocyte associated with paracetamol and hepatotoxicity

1) Confidence 0.35 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.56 Pain Relevance 0.56

Recently, it has been reported that NFV induces anchorage-independent growth and a G1 cell cycle arrest in melanoma cells by decreased activity of CDK2, a master kinase that regulates G1-S progression [32].

Negative_regulation (decreased) of CDK2 associated with skin cancer

2) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2931456 Disease Relevance 1.21 Pain Relevance 0

found in a plant native to India, Dysoxylum binectariferum, is a potent inhibitor of most CDKs, including CDK1, CDK2, CDK4, and CDK7 [73].

Negative_regulation (inhibitor) of CDK2

3) Confidence 0.22 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.11 Pain Relevance 0.15

Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006).

Negative_regulation (decrease) of CDK2

4) Confidence 0.21 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.17 Pain Relevance 0

Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006).

Negative_regulation (decrease) of cyclin dependent kinase 2

5) Confidence 0.21 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.17 Pain Relevance 0

Roscovitine (Seliciclib, CYC202) is a potent and remarkably selective inhibitor of CDK2/cyclin E, CDK7/cyclin H, CDK9/cyclin T1 and CDK5/p35-p25 [112, 113].

Negative_regulation (inhibitor) of CDK2

6) Confidence 0.20 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.61 Pain Relevance 0.05

More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.

Negative_regulation (inhibitors) of Cdk2 in BxPC-3

7) Confidence 0.08 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.06 Pain Relevance 0

General Comments

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