INT114880
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced. | |||||||||||||||
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Recently, it has been reported that NFV induces anchorage-independent growth and a G1 cell cycle arrest in melanoma cells by decreased activity of CDK2, a master kinase that regulates G1-S progression [32]. | |||||||||||||||
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found in a plant native to India, Dysoxylum binectariferum, is a potent inhibitor of most CDKs, including CDK1, CDK2, CDK4, and CDK7 [73]. | |||||||||||||||
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Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006). | |||||||||||||||
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Other important mechanisms of action comprise the internalization and degradation of Her2 receptor protein (Cuello et al 2001), decrease of cyclin dependent kinase 2 (CDK2) activity via p27 induction (Lane et al 2001), blockade of downstream Her2 signaling pathways (Yakes et al 2002), and inhibition of DNA repair (Nahta et al 2006). | |||||||||||||||
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Roscovitine (Seliciclib, CYC202) is a potent and remarkably selective inhibitor of CDK2/cyclin E, CDK7/cyclin H, CDK9/cyclin T1 and CDK5/p35-p25 [112, 113]. | |||||||||||||||
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More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1. | |||||||||||||||
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