INT114881
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Linalool did not induce significant changes in Akt expression and phopshorylation though a trend toward an increased ratio of phosphorylated versus total Akt was observed in SNL animals treated with linalool, in comparison to SNL alone or sham. | |||||||||||||||
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Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury. | |||||||||||||||
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The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels. | |||||||||||||||
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To further confirm the role of Akt signaling in arsenic-induced inhibition of myogenesis, the constitutively active form of Akt was overexpressed in C2C12 myoblastic cells. | |||||||||||||||
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Those authors reported that transfection of myr Akt in chicken embryo fibroblasts dramatically enhanced myotube formation and expression of the muscle-specific proteins MyoD, creatine kinase, MHC, and desmin. | |||||||||||||||
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We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind. | |||||||||||||||
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Overexpression of anti-apoptotic proteins including Bcl-2 family members and AKT/PKB pathway agonists have been found in a variety of human cancers including pancreas[25], breast[26], prostate [27] and lung[28]. | |||||||||||||||
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The expression level of total Akt protein was significantly decreased in the diabetic mice aorta, but those for the p85 and p110gamma subunits of PI3-K were not. | |||||||||||||||
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In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation. | |||||||||||||||
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Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008). | |||||||||||||||
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Transfection with a constitutively active form of Akt (c.a. | |||||||||||||||
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Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008). | |||||||||||||||
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Akt) enhanced myotube formation (Figure 7A), creatine kinase activity (Figure 7B), and MHC expression (Figure 6A) during myogenesis, and effectively antagonized the myogenesis inhibition induced by 0.5 ? | |||||||||||||||
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In the present study, the phosophorylation levels of Akt (Ser473) and GSK3? | |||||||||||||||
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Phosphorylation levels of Akt and GSK3? | |||||||||||||||
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However, the phosphorylation levels of Akt (Ser473) and GSK3? | |||||||||||||||
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Using Western blot analysis, we evaluated the phosohorylation levels of Akt and GSK3? | |||||||||||||||
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KO mice, we assessed the phosophorylation levels of Akt and GSK3? | |||||||||||||||
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Activation of the PI3K-Akt pathway by TGF-? | |||||||||||||||
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PI3K/AKT signaling that may also account for the inhibitory action of PPAR? | |||||||||||||||
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General Comments
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