INT114881

Context Info Confidence 0.78 First Reported 2003 Last Reported 2010 Negated 5 Speculated 10 Reported most in Body Documents 227 Total Number 238 Disease Relevance 102.49 Pain Relevance 31.81

transport (Akt1) aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)

Anatomy Link Frequency fat 6 kidney 4 spinal cord 4 Mouse 4 brain 4 Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 665 100.00 Clonidine 12 100.00 neuralgia 8 100.00 Morphine 736 99.92 Spinal cord 727 99.92 opioid receptor 673 99.80 agonist 250 99.48 Arthritis 452 99.42 Hippocampus 211 99.24 antagonist 198 99.24

Disease Link Frequency Relevance Heat Apoptosis 1730 100.00 Repression 22 100.00 Plasmodium Infection 17 100.00 Cancer 3637 99.98 Prostate Cancer 37 99.86 Adenocarcinoma 766 99.84 Myeloid Leukemia 547 99.84 Frailty 129 99.78 Infection 212 99.68 Metastasis 749 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Linalool did not induce significant changes in Akt expression and phopshorylation though a trend toward an increased ratio of phosphorylated versus total Akt was observed in SNL animals treated with linalool, in comparison to SNL alone or sham.

Gene_expression (expression) of Akt associated with spinal nerve ligature

1) Confidence 0.78 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607973 Disease Relevance 0.90 Pain Relevance 1.46

Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury.

Gene_expression (Expression) of Akt in sensory neurons associated with neuralgia, nervous system injury, peripheral nerve injury and spinal cord

2) Confidence 0.78 Published 2009 Journal Neurosignals Section Title Doc Link 19346757 Disease Relevance 0.65 Pain Relevance 0.81

The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.

Gene_expression (expression) of Akt in aortas associated with diabetes mellitus and clonidine

3) Confidence 0.78 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.98 Pain Relevance 0.36

To further confirm the role of Akt signaling in arsenic-induced inhibition of myogenesis, the constitutively active form of Akt was overexpressed in C2C12 myoblastic cells.

Gene_expression (overexpressed) of Akt

4) Confidence 0.77 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.06 Pain Relevance 0

Those authors reported that transfection of myr Akt in chicken embryo fibroblasts dramatically enhanced myotube formation and expression of the muscle-specific proteins MyoD, creatine kinase, MHC, and desmin.

Gene_expression (transfection) of Akt in embryo

5) Confidence 0.77 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.16 Pain Relevance 0

We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.

Gene_expression (expression) of AKT

6) Confidence 0.75 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0

Overexpression of anti-apoptotic proteins including Bcl-2 family members and AKT/PKB pathway agonists have been found in a variety of human cancers including pancreas[25], breast[26], prostate [27] and lung[28].

Gene_expression (Overexpression) of AKT in lung associated with cancer, agonist and apoptosis

7) Confidence 0.75 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.23 Pain Relevance 0.05

The expression level of total Akt protein was significantly decreased in the diabetic mice aorta, but those for the p85 and p110gamma subunits of PI3-K were not.

Gene_expression (expression) of Akt in aorta associated with diabetes mellitus

8) Confidence 0.71 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.55 Pain Relevance 0.41

In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation.

Gene_expression (protein) of Akt

9) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.50 Pain Relevance 0.03

Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008).

Gene_expression (found) of Akt in skeletal muscle associated with birth weight

10) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.17 Pain Relevance 0.03

Transfection with a constitutively active form of Akt (c.a.

Gene_expression (Transfection) of Akt

11) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.07 Pain Relevance 0

Altered PI3K/Akt signaling is also found in the skeletal muscle of young men with low birth weight (Jensen et al. 2008).

Gene_expression (/) of Akt in skeletal muscle associated with birth weight

12) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.17 Pain Relevance 0.03

Akt) enhanced myotube formation (Figure 7A), creatine kinase activity (Figure 7B), and MHC expression (Figure 6A) during myogenesis, and effectively antagonized the myogenesis inhibition induced by 0.5 ?

Gene_expression (antagonized) of Akt in myotube

13) Confidence 0.67 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.08 Pain Relevance 0

In the present study, the phosophorylation levels of Akt (Ser473) and GSK3?

Gene_expression (levels) of Akt

14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.98 Pain Relevance 0.07

Phosphorylation levels of Akt and GSK3?

Gene_expression (levels) of Akt

15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.97 Pain Relevance 0.11

However, the phosphorylation levels of Akt (Ser473) and GSK3?

Gene_expression (levels) of Akt

16) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.73 Pain Relevance 0.09

Using Western blot analysis, we evaluated the phosohorylation levels of Akt and GSK3?

Gene_expression (levels) of Akt

17) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.79 Pain Relevance 0.11

KO mice, we assessed the phosophorylation levels of Akt and GSK3?

Gene_expression (levels) of Akt associated with targeted disruption

18) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.26 Pain Relevance 0.17

Activation of the PI3K-Akt pathway by TGF-?

Gene_expression (pathway) of Akt

19) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2763124 Disease Relevance 0.71 Pain Relevance 0.03

PI3K/AKT signaling that may also account for the inhibitory action of PPAR?

Gene_expression (/) of AKT

20) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.63 Pain Relevance 0.05

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