INT114882

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 21.29
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
neurons 6
lymph node 4
kidney 4
embryo 2
muscle 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 137 100.00 Very High Very High Very High
opioid receptor 84 99.92 Very High Very High Very High
agonist 78 99.48 Very High Very High Very High
Hippocampus 55 99.24 Very High Very High Very High
Inflammatory response 59 98.94 Very High Very High Very High
midbrain 18 98.76 Very High Very High Very High
Paracetamol 13 98.20 Very High Very High Very High
Arthritis 29 97.64 Very High Very High Very High
Morphine 77 96.48 Very High Very High Very High
Inflammation 208 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 275 100.00 Very High Very High Very High
Cancer 698 99.88 Very High Very High Very High
Frailty 25 99.78 Very High Very High Very High
Glaucoma 7 99.60 Very High Very High Very High
Metastasis 211 99.52 Very High Very High Very High
Mesothelioma 110 99.30 Very High Very High Very High
Injury 55 99.24 Very High Very High Very High
Hypertrophy 34 98.92 Very High Very High Very High
INFLAMMATION 272 98.76 Very High Very High Very High
Pancreatic Cancer 103 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further confirm the role of Akt signaling in arsenic-induced inhibition of myogenesis, the constitutively active form of Akt was overexpressed in C2C12 myoblastic cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Akt
1) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.06 Pain Relevance 0
Transfection with a constitutively active form of Akt (c.a.
Positive_regulation (Transfection) of Gene_expression (Transfection) of Akt
2) Confidence 0.50 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.07 Pain Relevance 0
Those authors reported that transfection of myr Akt in chicken embryo fibroblasts dramatically enhanced myotube formation and expression of the muscle-specific proteins MyoD, creatine kinase, MHC, and desmin.
Positive_regulation (transfection) of Gene_expression (transfection) of Akt in embryo
3) Confidence 0.50 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.16 Pain Relevance 0
To the best of our knowledge, the present study is the first to show an in-vivo link between activation of the A3AR, inhibition of PKB/Akt and downstream signaling pathways leading to apoptosis in AIA.
Positive_regulation (activation) of Neg (inhibition) Gene_expression (inhibition) of PKB/Akt associated with apoptosis and arthritis
4) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.20 Pain Relevance 0.33
Overexpression of anti-apoptotic proteins including Bcl-2 family members and AKT/PKB pathway agonists have been found in a variety of human cancers including pancreas[25], breast[26], prostate [27] and lung[28].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of AKT in lung associated with cancer, agonist and apoptosis
5) Confidence 0.49 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.23 Pain Relevance 0.05
Activation of the PI3K-Akt pathway by TGF-?
Positive_regulation (Activation) of Gene_expression (pathway) of Akt
6) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2763124 Disease Relevance 0.72 Pain Relevance 0.03
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of AKT
7) Confidence 0.49 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
Expression of Akt, a downstream target of PI-3K, was increased in both WT and TNFR1-/- mice in response to acetaminophen.
Positive_regulation (increased) of Gene_expression (Expression) of Akt associated with paracetamol
8) Confidence 0.45 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.54 Pain Relevance 0.93
are one of target proteins of lithium; lithium increases the phosphorylation levels of Akt and GSK3?
Positive_regulation (increases) of Gene_expression (levels) of Akt
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.03 Pain Relevance 0.07
Using Western blot analysis, we evaluated the phosohorylation levels of Akt and GSK3?
Positive_regulation (evaluated) of Gene_expression (levels) of Akt
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.86 Pain Relevance 0.11
A previous study overexpressed a constitutively active form of the oncoprotein Akt/PKB in neurons of the ventral midbrain of adult mice using adeno-associated virus transduction [12].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Akt in neurons associated with midbrain
11) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.32 Pain Relevance 0.25
Immunoblotting revealed that RFB increased expression of phosphorylated AKT at concentrations that stimulated psca promoter activity, and that increased PSCA protein expression.
Positive_regulation (increased) of Gene_expression (expression) of AKT
12) Confidence 0.37 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16949054 Disease Relevance 0.46 Pain Relevance 0.26
This indicates that the MOR is coupled to the production of NO via the Akt-nNOS pathway.
Positive_regulation (coupled) of Gene_expression (production) of Akt associated with opioid receptor
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 0.92
Tumors exhibited increased association of Egfr with clathrin heavy chain (CHC), Gab1, and p85alpha, the regulatory subunit of phosphoinositide 3-kinase (PI3K), and tumors also overexpressed c-Src, PDK1, and Akt.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Akt associated with cancer
14) Confidence 0.36 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15294912 Disease Relevance 1.26 Pain Relevance 0.06
Significantly, insulin-stimulated PKB/Akt activation was not decreased in Irs2-/- kidney at 5-6 wk (Fig. 6), and no changes in basal PKB/Akt/GSK3?
Positive_regulation (stimulated) of Gene_expression (activation) of PKB/Akt in kidney
15) Confidence 0.35 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.16 Pain Relevance 0
Significantly, insulin-stimulated PKB/Akt activation was not decreased in Irs2-/- kidney at 5-6 wk (Fig. 6), and no changes in basal PKB/Akt/GSK3?
Positive_regulation (stimulated) of Gene_expression (activation) of PKB/Akt in kidney
16) Confidence 0.35 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.22 Pain Relevance 0
Electroporating constitutively active PKB in to adult rat skeletal muscle increases muscle mass and protects against unloading/denervation induced atrophy [6], [7], overexpressing constitutively active PKB in C2C12 myotubes increases myotube diameter [8] and in both instances these effects are antagonised by PI(3,4,5)P3 phosphatases [6], [8].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PKB in muscle associated with frailty
17) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.21 Pain Relevance 0
Expression of insulin-like growth factor-1 and phosphorylation of Akt, mammalian target of rapamycin, and p70S6K were increased following synergist ablation, but were not affected by NS-398.
Positive_regulation (increased) of Gene_expression (Expression) of Akt
18) Confidence 0.32 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19176887 Disease Relevance 0.76 Pain Relevance 0.25
RFB activation of the psca promoter could be attenuated by co-transfection of dominant-negative akt and h-ras constructs, but not by dominant-negative mek1 plasmids.
Positive_regulation (co-transfection) of Gene_expression (co-transfection) of akt
19) Confidence 0.32 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16949054 Disease Relevance 0.50 Pain Relevance 0.26
The activated AKT expressed in peripheral nerve terminals and DRG peptide-containing and small non-peptide-containing neurons.
Positive_regulation (activated) of Gene_expression (expressed) of AKT in neurons
20) Confidence 0.32 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.43

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