INT114883

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Pik3r1) cytosol (Akt1, Pik3r1) signal transduction (Akt1, Pik3r1)
nucleus (Akt1, Pik3r1) plasma membrane (Akt1, Pik3r1) kinase activity (Akt1, Pik3r1)
Akt1 (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 97.60 Very High Very High Very High
cytokine 2 84.16 Quite High
fibrosis 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 75.00 Quite High
Toxicity 2 75.00 Quite High
Cancer 1 75.00 Quite High
Hepatotoxicity 3 73.12 Quite High
Injury 11 64.80 Quite High
Muscular Dystrophy 1 53.84 Quite High
Targeted Disruption 1 52.08 Quite High
Muscle Disease 4 48.16 Quite Low
Dwarfism 1 46.40 Quite Low
Muscular Atrophy 2 42.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Jiang et al. (1999) further indicated that serine/threonine protein kinase Akt, a downstream target of PI3K, can substitute for PI3K in the stimulation of myogenesis.
Akt Regulation (target) of PI3K
1) Confidence 0.16 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.12 Pain Relevance 0
Expression of Akt, a downstream target of PI-3K, was increased in both WT and TNFR1-/- mice in response to acetaminophen.
Akt Regulation (target) of PI-3K associated with paracetamol
2) Confidence 0.04 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.53 Pain Relevance 0.92

General Comments

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