INT114898

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.69
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
sacroiliac joints 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 219 100.00 Very High Very High Very High
backache 1 97.08 Very High Very High Very High
Arthritis 52 96.96 Very High Very High Very High
chemokine 7 96.48 Very High Very High Very High
spinal inflammation 33 94.96 High High
Etanercept 20 77.84 Quite High
Inflammation 43 72.80 Quite High
Infliximab 2 70.72 Quite High
cINOD 8 69.00 Quite High
antagonist 4 68.48 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 38 97.08 Very High Very High Very High
Arthritis 55 96.96 Very High Very High Very High
Pressure And Volume Under Development 16 90.16 High High
Necrosis 6 87.60 High High
Cancer 7 87.24 High High
Targeted Disruption 1 86.04 High High
Disease 51 73.44 Quite High
Hypertrophy 2 73.36 Quite High
INFLAMMATION 50 63.56 Quite High
Pain 5 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA and TNF protein in the sacroiliac joints demonstrated that TNF-?
Regulation (sacroiliac joints) of Transcription (protein) of TNF in sacroiliac joints
1) Confidence 0.35 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580004 Disease Relevance 1.46 Pain Relevance 1.22
Other receptors include class II receptors that bind the interferon and IL10 families, the immunoglobulin superfamily receptors that bind the IL1 cytokine family, TNF family receptors, TGF?
Regulation (interferon) of Transcription (receptors) of TNF associated with cytokine
2) Confidence 0.35 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.13 Pain Relevance 0.61
Further our results indicated that shikonin suppressed the basal transcription and activator-regulated transcription of TNF-alpha by inhibiting the binding of transcription factor IID protein complex (TATA box-binding protein) to TATA box.
Regulation (regulated) of Transcription (transcription) of TNF-alpha
3) Confidence 0.23 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.35 Pain Relevance 0.12
Administration of the anti-TNF was also significantly effective at lowering serum IL-6 levels.


Regulation (effective) of Transcription (Administration) of anti-TNF
4) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.76 Pain Relevance 0.24

General Comments

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