INT1149

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Context Info
Confidence 0.37
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 13.67
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 2
Macrophages 1
ECs 1
capillary 1
astrocytes 1
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 9 100.00 Very High Very High Very High
fortral 4 100.00 Very High Very High Very High
narcan 8 99.76 Very High Very High Very High
Inflammation 205 99.52 Very High Very High Very High
Hippocampus 4 98.68 Very High Very High Very High
Clonidine 5 98.62 Very High Very High Very High
Endocannabinoid 50 97.24 Very High Very High Very High
cytokine 48 96.52 Very High Very High Very High
chemokine 75 95.68 Very High Very High Very High
tolerance 3 92.20 High High
Disease Link Frequency Relevance Heat
Cancer 510 100.00 Very High Very High Very High
Shock 38 100.00 Very High Very High Very High
INFLAMMATION 229 99.52 Very High Very High Very High
Adhesions 137 98.52 Very High Very High Very High
Atherosclerosis 8 98.32 Very High Very High Very High
Hyperglycemia 3 96.00 Very High Very High Very High
Increased Venous Pressure Under Development 48 95.44 Very High Very High Very High
Hyperlipidemia 3 95.28 Very High Very High Very High
Stress 42 94.12 High High
Insulin Resistance 39 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The psychomotor stimulant effects of clonidine and/or apomorphine, given after reserpine was, however, enhanced by pretreatment with ECS X VII, DAY 1.
ECS X VII Binding (pretreatment) of associated with shock and clonidine
1) Confidence 0.37 Published 1975 Journal J. Neural Transm. Section Abstract Doc Link 164522 Disease Relevance 1.29 Pain Relevance 0.43
The aim of the present study was to investigate the effect of chronic treatment with electroconvulsive shock (ECS) or lithium on (+)[3H]pentazocine binding to sigma-1 receptors in the rat hippocampus.
ECS Binding (binding) of in hippocampus associated with fortral, shock and hippocampus
2) Confidence 0.30 Published 1996 Journal Pol J Pharmacol Section Abstract Doc Link 9112664 Disease Relevance 0.37 Pain Relevance 0.39
In vitro studies demonstrate that contact between ECs and pericytes or astrocytes leads to TGF-?
ECs Binding (contact) of in astrocytes
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.08 Pain Relevance 0
1 signaling via endoglin or ALK-1 on ECs is associated with vessel destabilization, EC proliferation and migration, by limiting TGF-?
ECs Binding (signaling) of
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.23 Pain Relevance 0
Furthermore, ALK5 inhibition led to a significant decrease in the number of mesenchymal cells associated with ECs in the 3-dimensional model, suggesting that TGF-?
ECs Binding (associated) of in mesenchymal cells
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.52 Pain Relevance 0
1 signaling via endoglin or ALK-1 on ECs is associated with vessel destabilization, EC proliferation and migration, by limiting TGF-?
ECs Binding (associated) of
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.23 Pain Relevance 0
Electroconvulsive shock (ECS) and H-endorphin-induced analgesia: unconventional interactions with naloxone.
ECS Binding (interactions) of associated with shock, narcan and analgesia
7) Confidence 0.11 Published 1982 Journal Eur. J. Pharmacol. Section Title Doc Link 6889535 Disease Relevance 0.68 Pain Relevance 1.41
Three daily ECSs produced brief downregulation, which has implications for receptor dynamics as a function of the ECS schedule.
ECS Binding (function) of associated with shock
8) Confidence 0.10 Published 2000 Journal J ECT Section Abstract Doc Link 11005049 Disease Relevance 0.60 Pain Relevance 0.12
In these model conditions, activated 12/15LO regulates monocyte attachment to ECs in part by increasing expression of adhesion molecule ICAM-1 on the surface of ECs via activation of RhoA and NF-?
ECs Binding (attachment) of in ECs associated with adhesions
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.83 Pain Relevance 0.24
We studied the activity of the ECS in human volunteers (n?
ECS Binding (activity) of
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873996 Disease Relevance 0.79 Pain Relevance 0.20
TSP-1 is a large molecular weight glycoprotein that inhibits the proliferation and migration of ECs by interacting with CD36 expressed on the cell surface; CD36 is a PPAR?
ECs Binding (proliferation) of
11) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.25 Pain Relevance 0.03
The phage display peptide libraries have been used to identify peptides that home to tumors through the circulation and that specifically bind to the tumor ECs or lymphatic cells [146,147].
ECs Binding (bind) of associated with cancer
12) Confidence 0.02 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.68 Pain Relevance 0.04
The antiangiogenic effects of THBS1 appear to be localized to a peptide sequence containing the type I repeats domain, which binds CD36 on ECs [37].
ECs Binding (binds) of
13) Confidence 0.02 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.34 Pain Relevance 0.04
These alterations suggested that a possible interaction between ECs and effector immune cells might play an important role in the pathogenesis of the myocellular lesion and of the microangiopathy observed in this model [80].


ECs Binding (interaction) of in immune cells
14) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.88 Pain Relevance 0.10
The study nurse faxes the patient's leg measurements to the stocking supplier, who then ships the assigned pair of ECS to the patient (i.e. correct size, according to patient's measurements; active or inactive stocking, according to patient's treatment code).
ECS Binding (pair) of in leg
15) Confidence 0.01 Published 2007 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1940263 Disease Relevance 0.64 Pain Relevance 0.07
ECs play a crucial role in leukocyte homing to tissues, through adhesive interactions with these cells.
ECs Binding (interactions) of in leukocyte
16) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.59 Pain Relevance 0.43
Chemoattractants bind to the surface of ECs, which present them to circulating PMNs.
ECs Binding (bind) of
17) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.70 Pain Relevance 0.31
The carbohydrate-rich layer which extends into the capillary lumen provides anionic sites (i.e. carboxyl groups of sialic acid residues) for the binding of cationic substances to the luminal side of cerebral ECs.
ECs Binding (binding) of in capillary
18) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
Macrophages and ECs bind to ?
ECs Binding (bind) of in Macrophages
19) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 1.97 Pain Relevance 0.09

General Comments

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