INT11490

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 3.61
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
plasma 1
neuronal 1
uterus 1
cleavage 1
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 12 100.00 Very High Very High Very High
bradykinin 8 100.00 Very High Very High Very High
tetrodotoxin 156 99.98 Very High Very High Very High
local anesthetic 22 99.98 Very High Very High Very High
qutenza 7 99.86 Very High Very High Very High
cocaine 1 98.84 Very High Very High Very High
Pain 7 97.92 Very High Very High Very High
Neuronal excitability 1 96.12 Very High Very High Very High
Inflammation 8 95.04 Very High Very High Very High
nMDA receptor 2 94.56 High High
Disease Link Frequency Relevance Heat
Cancer 70 98.84 Very High Very High Very High
Disease 141 98.20 Very High Very High Very High
Syndrome 7 98.12 Very High Very High Very High
Pain 6 97.92 Very High Very High Very High
Hypersensitivity 5 97.54 Very High Very High Very High
INFLAMMATION 7 95.04 Very High Very High Very High
Nicotine Addiction 1 94.80 High High
Breast Cancer 11 92.00 High High
Metastasis 4 90.08 High High
Hyperalgesia 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrated a statistically significant association of the selenium resistance with four SNPs in the intronic regions of four genes; (a) KCNMA1 (also known as BK-and Maxi K+ channel), a large conductance, voltage and Ca2+-sensitive K+ channel located on the plasma membrane.
KCNMA1 Binding (association) of in plasma
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.58 Pain Relevance 0
Finally, given the strong functional relationship among the candidate genes, using statistical methods, we have also investigated the gene-gene interaction (epistasis), demonstrating possible interactions, between the SNPs of KCNMA1 and AKAP6 as well as AKAP6 and SGCD, under the additive model.
KCNMA1 Binding (interactions) of
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.43 Pain Relevance 0
For example, alteration of KCNMA1 function has been associated with several complex human disorders including cancer.
KCNMA1 Binding (associated) of associated with cancer
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.00 Pain Relevance 0
AKAP6, located on the ER/SR, acts as an adapter molecule in co-localization of the PKA, which also phosphorylates and regulates the activity of KCNMA1 [44], [45].
KCNMA1 Binding (activity) of
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.18 Pain Relevance 0
Expression of this variant mRNA accounted for only 1% of total Maxi-K ?
Maxi-K Binding (accounted) of
5) Confidence 0.28 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
The hypothetical link of KCNMA1 with Lobeline appears to be consistent with a recent report demonstrating the role of KCNMA1 in neuronal excitability [56].
KCNMA1 Binding (link) of in neuronal associated with neuronal excitability
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715883 Disease Relevance 0.09 Pain Relevance 0.10
In dextran sulfate-activated plasma, Neurotropin inhibited the formation of BK, the cleavage of high molecular weight kininogen (HK) and the formation of kallikrein-C1 inhibitor and activated coagulation factor XII (FXIIa)-C1 inhibitor complexes.
BK Binding (formation) of in cleavage associated with bradykinin
7) Confidence 0.05 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.42 Pain Relevance 0.27
These data suggest that the ameliorating effects of Neurotropin in allergic disorders and pain syndromes may be related to this ability to inhibit activation of the K-K cascade and consequently the formation of BK.
BK Binding (formation) of associated with pain, syndrome, hypersensitivity and bradykinin
8) Confidence 0.04 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.47 Pain Relevance 0.29
How the two concepts of CSR and SLO are supposed to apply to community health and interact through their business-oriented logic is best clarified in an illustrative paper from the British Overseas Development Institute:

"Social investments in local health (...), skills and infrastructure improve the capacity to absorb positive spillovers from and enhance linkages with businesses.

SLO Binding (interact) of
9) Confidence 0.03 Published 2008 Journal Global Health Section Body Doc Link PMC2596095 Disease Relevance 0 Pain Relevance 0
We also determine whether prenylamine and local anesthetics interact with a common binding site on the Nav1.5 channel by analyzing prenylamine block on mutant hNav1.5 channels that have substitution mutations in amino acids at the putative local anesthetic binding sites.
channel Spec (whether) Binding (interact) of associated with local anesthetic
10) Confidence 0.02 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12130695 Disease Relevance 0 Pain Relevance 0.57
The N-methyl-D-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits.
channel Binding (interacts) of
11) Confidence 0.01 Published 2003 Journal Pharmacol. Ther. Section Abstract Doc Link 12493535 Disease Relevance 0.06 Pain Relevance 0.15
Channel activity, expression, association, and localization were examined by patch-clamping, Western blot, immunoprecipitation, and immunofluorescence, respectively.


Channel Binding (association) of
12) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0.03
Our recent findings that the maxi-K channel resides in caveolae on the MSMC, and that it associates with the actin cytoskeleton to regulate channel activity, raise the possibility that this channel may interact dynamically with associated proteins to regulate the transition of the uterus from a quiescent to a contractile state.
channel Binding (interact) of in uterus
13) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
For example, an association of the channel with accessory beta subunits promotes channel activity [3].
channel Binding (association) of
14) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0.04
Direct interaction of adenosine with the TRPV1 channel protein.
channel Binding (interaction) of associated with adenocard
15) Confidence 0.00 Published 2004 Journal J. Neurosci. Section Title Doc Link 15071115 Disease Relevance 0.37 Pain Relevance 1.15
Such conformational flexibility may be important for toxin–channel interactions.
channel Binding (interactions) of
16) Confidence 0.00 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.27
Such mechanism may provide a link between the “trapped ion” model of TTX binding and state-dependent channel modulation by the toxin.

3.

channel Binding (binding) of associated with tetrodotoxin
17) Confidence 0.00 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.47

General Comments

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