INT114901

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.45
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TBP) cell death (TBP) DNA binding (TBP)
transcription factor binding (TBP) cytoplasm (TBP)
Anatomy Link Frequency
cleavage 2
TBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 7 89.96 High High
Inflammation 12 79.84 Quite High
cINOD 1 49.04 Quite Low
Central nervous system 34 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 36 100.00 Very High Very High Very High
Atherosclerotic Plaque 50 98.92 Very High Very High Very High
Apoptosis 1 95.32 Very High Very High Very High
Stress 12 92.88 High High
Infection 39 89.28 High High
Cirrhosis 8 85.32 High High
Targeted Disruption 7 83.84 Quite High
Atherosclerosis 78 81.44 Quite High
Aggression 3 78.52 Quite High
Cancer 14 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primers for TBP, RPLP0, and the 240 target genes were chosen with the assistance of the Oligo 5.0 computer program (National Biosciences, Plymouth, MN).
TBP Binding (Primers) of
1) Confidence 0.17 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.73 Pain Relevance 0
Moreover, inhibition of host cell transcription occurs via inactivation of transcription factor TFIIIC [40] and cleavage of the TATA box binding protein (TBP) by 3Cpro [199].
TBP Binding (inactivation) of in cleavage
2) Confidence 0.11 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.09 Pain Relevance 0
Moreover, inhibition of host cell transcription occurs via inactivation of transcription factor TFIIIC [40] and cleavage of the TATA box binding protein (TBP) by 3Cpro [199].
box binding protein Binding (inactivation) of in cleavage
3) Confidence 0.09 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.09 Pain Relevance 0
The mouse SR-BII isoform binds HDL and mediates both cholesterol uptake and efflux but seems to be less efficient than SR-BI [23].
HDL Binding (binds) of associated with disorder of lipid metabolism
4) Confidence 0.03 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.52 Pain Relevance 0.04
SR-BI mainly binds phospholipid-rich HDL particles, whereas ABCA1 preferably uses lipid-poor HDL particles as cholesterol acceptors [31].
HDL Binding (binds) of associated with disorder of lipid metabolism
5) Confidence 0.03 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.72 Pain Relevance 0
Further our results indicated that shikonin suppressed the basal transcription and activator-regulated transcription of TNF-alpha by inhibiting the binding of transcription factor IID protein complex (TATA box-binding protein) to TATA box.
box-binding Binding (binding) of
6) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

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