INT114909

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.37
Pain Relevance 0.66

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aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
joints 2
fibroblasts 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 95.72 Very High Very High Very High
Arthritis 42 94.40 High High
Inflammation 92 93.56 High High
fibrosis 25 91.60 High High
melanocortin 1 receptor 1 85.52 High High
Neuropeptide 4 75.00 Quite High
Inflammatory response 1 44.64 Quite Low
bDMF 24 5.00 Very Low Very Low Very Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
cva 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 97.68 Very High Very High Very High
INFLAMMATION 94 96.60 Very High Very High Very High
Arthritis 60 94.40 High High
Keloid Scars 3 92.16 High High
Fibrosis 36 67.40 Quite High
Interstitial Lung Diseases 143 62.80 Quite High
Injury 23 59.40 Quite High
Experimental Arthritis 2 42.28 Quite Low
Disease Progression 2 34.72 Quite Low
Pulmonary Fibrosis 8 25.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The joints of naïve rabbits receiving the highest dose of Ad.TGF-?
Negative_regulation (receiving) of Localization (dose) of TGF in joints
1) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.58 Pain Relevance 0.24
Each rabbit received the indicated dose of TGF-?
Negative_regulation (received) of Localization (dose) of TGF
2) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.21 Pain Relevance 0.11
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (as) of Localization (morphogens) of TGF
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of Localization (morphogens) of TGF
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
The MC-1R on fibroblasts appears to be functionally relevant because alpha-MSH increased the amount of intracellular cAMP, and coincubation with a synthetic peptide corresponding to the human Agouti signaling protein abrogated the inhibition of TGF-beta1-induced PICP secretion by alpha-MSH.
Negative_regulation (inhibition) of Localization (secretion) of TGF-beta1-induced in fibroblasts
5) Confidence 0.18 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645373 Disease Relevance 0.15 Pain Relevance 0.23
A consequence is the perpetuation of a vicious cycle with TGF-?
Negative_regulation (cycle) of Localization (perpetuation) of TGF
6) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.43 Pain Relevance 0.08

General Comments

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