INT11491

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 128
Total Number 132
Disease Relevance 60.41
Pain Relevance 58.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 10
blood 4
dorsal root ganglion 3
skin 2
nociceptors 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 1708 100.00 Very High Very High Very High
Pain 659 100.00 Very High Very High Very High
adenocard 271 100.00 Very High Very High Very High
qutenza 266 100.00 Very High Very High Very High
substance P 238 100.00 Very High Very High Very High
cytokine 114 100.00 Very High Very High Very High
Enkephalin 81 100.00 Very High Very High Very High
B1 receptor 57 100.00 Very High Very High Very High
Nerve growth factor 50 100.00 Very High Very High Very High
Inflammatory mediators 47 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 891 100.00 Very High Very High Very High
Pain 686 100.00 Very High Very High Very High
Hypersensitivity 48 100.00 Very High Very High Very High
Osteoarthritis 8 99.84 Very High Very High Very High
Angioedema 32 99.80 Very High Very High Very High
Hereditary Angioedema 657 99.70 Very High Very High Very High
Pulpitis 6 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 432 99.60 Very High Very High Very High
Diabetes Mellitus 556 99.54 Very High Very High Very High
Natriuresis 9 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the bradykinin (BK) B(2) receptor by kinins is associated with pathophysiological as well as pronounced beneficial effects.
Positive_regulation (Stimulation) of bradykinin associated with bradykinin
1) Confidence 0.67 Published 2002 Journal Curr. Med. Chem. Section Abstract Doc Link 11966453 Disease Relevance 0.42 Pain Relevance 0.48
The bradykinin B(1) receptor is rapidly induced after inflammation or tissue trauma and appears to play an important role in the maintenance of hyperalgesia in inflammatory conditions.
Positive_regulation (induced) of bradykinin associated with hyperalgesia, inflammation, injury and bradykinin
2) Confidence 0.67 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15341478 Disease Relevance 0.39 Pain Relevance 0.43
A new study finds that elevated levels of the opioid dynorphin can unexpectedly activate bradykinin receptors, contributing to the maintenance of neuropathic pain.
Positive_regulation (activate) of bradykinin associated with dynorphin, neuropathic pain, bradykinin and opioid
3) Confidence 0.67 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 17128281 Disease Relevance 0.27 Pain Relevance 0.64
Bradykinin stimulation of PS-1 (M146L) AD fibroblasts results in decreased MAPK activation relative to control fibroblasts
Positive_regulation (stimulation) of Bradykinin in fibroblasts associated with disease and bradykinin
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.62 Pain Relevance 0.08
Enalaprilat induced a significant increase in bradykinin levels in the dialysate, without affecting kallidin levels.
Positive_regulation (increase) of bradykinin associated with bradykinin
5) Confidence 0.61 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15475593 Disease Relevance 0.29 Pain Relevance 0.43
These observations suggest that the bradykinin system is activated during pulpitis and may contribute to pain and inflammation.
Positive_regulation (activated) of bradykinin associated with pain, inflammation, pulpitis and bradykinin
6) Confidence 0.61 Published 2000 Journal J Endod Section Abstract Doc Link 11471646 Disease Relevance 0.88 Pain Relevance 1.07
Bradykinin peptide levels were increased in the urine of patients with interstitial cystitis, suggesting a role for these peptides in the pathogenesis and/or symptomatology of this condition. 7.
Positive_regulation (increased) of Bradykinin in urine associated with interstitial cystitis and bradykinin
7) Confidence 0.57 Published 2001 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11903316 Disease Relevance 0.32 Pain Relevance 0.37
Likewise, cromolyn sodium (40 mg dry powder) also significantly reduced response to bradykinin, with a PD35 of 0.04 mumol (range, 0.13 to 0.31) after placebo and 0.39 mumol (range, 0.05 to 4.45) after SCG (p less than 0.05).
Positive_regulation (response) of bradykinin associated with bradykinin
8) Confidence 0.50 Published 1987 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3541715 Disease Relevance 0.18 Pain Relevance 0.65
However, okadaic acid blocked the bradykinin -evoked increase in resensitization of the second response to ATP (Figures 2A-B).
Positive_regulation (increase) of bradykinin associated with bradykinin
9) Confidence 0.50 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.48
In non-allodynic rats i.t. injection of M35 induced a significant mechanical allodynic state, which did not occur after injection of galanin, bradykinin, the bradykinin fragment(2-9) or saline.
Positive_regulation (injection) of bradykinin associated with bradykinin
10) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 11119688 Disease Relevance 0.45 Pain Relevance 0.68
In the normal rat, however, PGE2 potentiates the excitatory action of bradykinin and enhances the sensitizing effect of bradykinin on the responses of joint mechanoreceptors to mechanical stimulation when both substances are injected simultaneously.
Positive_regulation (enhances) of bradykinin in mechanoreceptors associated with bradykinin
11) Confidence 0.49 Published 1991 Journal Exp Brain Res Section Abstract Doc Link 2065745 Disease Relevance 0.31 Pain Relevance 0.27
In addition the enzyme hydrolyzes bradykinin, substance P, beta-endorphin, ACTH, and VIP.
Positive_regulation (hydrolyzes) of bradykinin associated with bradykinin and substance p
12) Confidence 0.49 Published 1996 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8806762 Disease Relevance 0 Pain Relevance 0.30
Hageman factor-->activated Hageman factor-->prekallikrein-->kallikrein-->high-molecular weight kininogen-->bradykinin.
Positive_regulation (activated) of bradykinin associated with bradykinin
13) Confidence 0.49 Published 1996 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 8737987 Disease Relevance 0.59 Pain Relevance 0.18
Kinins may also contribute to the immune system by acting as danger signals, and activating bradykinin receptors.
Positive_regulation (activating) of bradykinin in immune system associated with bradykinin
14) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18093865 Disease Relevance 1.36 Pain Relevance 0.41
It has been well demonstrated that the activation of TRPV1, via GPCRs for bradykinin, histamine, prostaglandin, and serotonin, is associated with sensitization of peripheral nociceptors during thermal and inflammatory hyperalgesia [8,15,16,31,32].
Positive_regulation (activation) of bradykinin in nociceptors associated with hyperalgesia, inflammation, nociceptor, serotonin and bradykinin
15) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.29 Pain Relevance 0.84
AN69-associated reactions are a second group, and are probably mediated by membrane-induced bradykinin generation coupled with ACE-inhibitor induced prolongation of bradykinin half-life.
Positive_regulation (membrane-induced) of bradykinin associated with bradykinin
16) Confidence 0.49 Published 1994 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8065604 Disease Relevance 0 Pain Relevance 0.10
Studies of the mechanism of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema: the effect of an ACE inhibitor on cutaneous responses to bradykinin, codeine, and histamine.
Positive_regulation (responses) of bradykinin associated with pressure and volume under development, bradykinin and codeine
17) Confidence 0.49 Published 1990 Journal J. Allergy Clin. Immunol. Section Title Doc Link 2185292 Disease Relevance 0.54 Pain Relevance 0.58
Substance-P induced a more pronounced flare reaction than bradykinin, whereas the latter induced more pain than substance-P.
Positive_regulation (induced) of bradykinin associated with pain and bradykinin
18) Confidence 0.49 Published 1991 Journal Cephalalgia Section Abstract Doc Link 1720708 Disease Relevance 0.63 Pain Relevance 0.90
Kinins are peptide hormones that exert pathophysiological as well as pronounced beneficial physiological effects, mainly by stimulation of bradykinin (BK) B(2) receptors.
Positive_regulation (stimulation) of bradykinin associated with bradykinin
19) Confidence 0.49 Published 2000 Journal Drug News Perspect. Section Abstract Doc Link 12937626 Disease Relevance 0.49 Pain Relevance 0.40
Hyperalgesia in non-obese diabetic (NOD) mice: a role for the inducible bradykinin B1 receptor.
Positive_regulation (inducible) of bradykinin associated with hyperalgesia, diabetes mellitus, b1 receptor and obesity
20) Confidence 0.49 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15878325 Disease Relevance 2.16 Pain Relevance 0.66

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