INT114910

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
macrophage 2
smooth muscle 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 100 99.90 Very High Very High Very High
fibrosis 3 97.08 Very High Very High Very High
melanocortin 1 receptor 1 76.24 Quite High
Neuropeptide 3 75.00 Quite High
cytokine 10 59.96 Quite High
metalloproteinase 5 27.36 Quite Low
Inflammation 54 8.32 Low Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emphysema 54 99.74 Very High Very High Very High
Keloid Scars 1 97.08 Very High Very High Very High
Atherosclerosis 6 92.32 High High
Apoptosis 14 88.92 High High
Death 5 66.64 Quite High
Pulmonary Disease 146 50.72 Quite High
Fibrosis 4 43.68 Quite Low
Sprains And Strains 13 41.68 Quite Low
Disease 23 39.08 Quite Low
Targeted Disruption 1 28.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study, however, we found that aspirin was unable to increase TGF-?
Neg (unable) Negative_regulation (unable) of Neg (unable) Positive_regulation (increase) of TGF associated with aspirin
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.31 Pain Relevance 0.41
The inductive activity of TGF-beta1 on collagen deposition and the number of dermal cells immunoreactive for vimentin and alpha-smooth muscle actin was significantly suppressed by injection of alpha-MSH.
Negative_regulation (suppressed) of Positive_regulation (inductive) of TGF-beta1 in smooth muscle
2) Confidence 0.18 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645373 Disease Relevance 0.10 Pain Relevance 0.19
6-null mice develop age-related emphysema through the loss of activation of latent TGF-beta which leads to an increase in macrophage MMP-12 expression [171].
Negative_regulation (loss) of Positive_regulation (activation) of TGF-beta in macrophage associated with emphysema
3) Confidence 0.02 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.51 Pain Relevance 0

General Comments

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