INT114922

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Crebbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 99.34 Very High Very High Very High
opioid receptor 10 98.88 Very High Very High Very High
Inflammation 29 86.56 High High
mu opioid receptor 2 78.12 Quite High
Physical dependence 1 74.40 Quite High
tolerance 3 73.44 Quite High
Analgesic 1 71.64 Quite High
Lasting pain 1 67.88 Quite High
Morphine 1 66.52 Quite High
Inflammatory response 2 58.12 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 99.34 Very High Very High Very High
Adhesions 2 90.16 High High
Necrosis 1 87.72 High High
Cancer 1 87.36 High High
INFLAMMATION 23 86.56 High High
Drug Dependence 1 74.40 Quite High
Endotoxemia 1 71.96 Quite High
Pain 1 67.88 Quite High
Sepsis 1 62.84 Quite High
Hemorrhagic Shock 23 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulus-induced activation of CREB can occur secondary to a variety of cellular stressors, including ischemia-reperfusion, and is mediated by phosphorylation of CREB at serine residue 133.10 The coactivator CREB-binding protein (CBP) and its paralogue p300 regulate transcription through selective interaction with individual transcription factors.
Phosphorylation (phosphorylation) of CBP associated with ischemia
1) Confidence 0.21 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.77 Pain Relevance 0.16
CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay.
Phosphorylation (phosphorylated) of CBP associated with opioid receptor
2) Confidence 0.19 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.14 Pain Relevance 0.79

General Comments

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