INT114926

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
signal transducer activity (Oprm1) signal transduction (Oprm1) nucleolus (Creb1)
Creb1 (Rattus norvegicus)
Oprm1 (Mus musculus)
Creb1 - S133A (1)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
mu opioid receptor 4 75.00 Quite High
tolerance 6 68.32 Quite High
Physical dependence 2 61.36 Quite High
Analgesic 2 58.60 Quite High
Lasting pain 2 54.84 Quite High
Morphine 2 53.48 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 61.36 Quite High
Pain 2 54.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction.
CREB Negative_regulation (abolished) of Positive_regulation (induction) of MOR associated with opioid receptor
1) Confidence 0.13 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.12 Pain Relevance 0.78
The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction.
CREB-S133A (S133A) Negative_regulation (abolished) of Positive_regulation (induction) of MOR associated with opioid receptor
2) Confidence 0.13 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.12 Pain Relevance 0.78

General Comments

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