INT114927

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.28
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) DNA binding (Creb1)
signal transducer activity (Oprm1) signal transduction (Oprm1) nucleolus (Creb1)
Oprm1 (Mus musculus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 30 100.00 Very High Very High Very High
tolerance 9 96.96 Very High Very High Very High
mu opioid receptor 6 76.08 Quite High
Physical dependence 3 72.36 Quite High
Analgesic 3 69.60 Quite High
Lasting pain 3 65.84 Quite High
Morphine 3 64.48 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 72.36 Quite High
Pain 3 65.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, this study demonstrated that fentanyl-triggered MOR gene induction was mediated by the sequential activation of CREB and the binding of CREB and CBP to MOR promoter, thus provides direct evidence for lower propensity of fentanyl to produce tolerance.
Positive_regulation (activation) of MOR promoter Binding (binding) of CREB associated with tolerance and opioid receptor
1) Confidence 0.17 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0 Pain Relevance 0.51
CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay.
Positive_regulation (increased) of endogenous MOR promoter Binding (binding) of CREB associated with opioid receptor
2) Confidence 0.15 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.14 Pain Relevance 0.78
CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay.
Positive_regulation (increased) of endogenous MOR promoter Binding (binding) of CREB associated with opioid receptor
3) Confidence 0.15 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.14 Pain Relevance 0.78

General Comments

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