INT11493

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 9.22
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK1) nucleus (KLK1)
Anatomy Link Frequency
plasma 5
TMJ 1
capillary 1
synovial joints 1
KLK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 10 99.84 Very High Very High Very High
bradykinin 35 99.66 Very High Very High Very High
Clonidine 4 99.56 Very High Very High Very High
Pain 23 99.38 Very High Very High Very High
Perioperative pain 1 98.88 Very High Very High Very High
Dopamine 6 98.40 Very High Very High Very High
Analgesic 2 97.48 Very High Very High Very High
cINOD 2 96.24 Very High Very High Very High
antagonist 7 95.68 Very High Very High Very High
Inflammation 15 93.88 High High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 10 99.84 Very High Very High Very High
Streptococcus Infection 3 99.84 Very High Very High Very High
Pain 18 99.38 Very High Very High Very High
Hypersensitivity 10 99.20 Very High Very High Very High
Septic Shock 6 99.00 Very High Very High Very High
Post Operative Pain 1 98.88 Very High Very High Very High
Disseminated Intravascular Coagulation 9 98.76 Very High Very High Very High
Stress 5 98.76 Very High Very High Very High
Osteoarthritis 3 97.68 Very High Very High Very High
Cv General 2 Under Development 3 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results clearly demonstrated increased levels of PA, plasmin and kallikrein activities in the synovial fluid of patients with ID and OA, and suggest that these enzymes may be involved in the pathogenesis of synovitis, as well as the resorption of cartilage and bone in TMJ.
Positive_regulation (increased) of kallikrein in TMJ associated with snapping jaw, synovitis and osteoarthritis
1) Confidence 0.67 Published 2001 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11518356 Disease Relevance 0.69 Pain Relevance 0.33
Increases in urinary kallikrein and kinin excretion showed a significant relationship with the consumed plasma fibrinogen levels (r = -0.51, P less than 0.01 and r = -0.58, P less than 0.01, respectively), and it was suggested that activation of the glandular kallikrein-kinin system caused by abrupt DIC-like changes in the hemostatic system might play a role in manifestations of temporary complications occurring with the use of hemostatic agents containing thrombin.
Positive_regulation (Increases) of kallikrein in plasma associated with disseminated intravascular coagulation
2) Confidence 0.67 Published 1990 Journal Gastroenterol. Jpn. Section Abstract Doc Link 2227247 Disease Relevance 0.57 Pain Relevance 0.08
Increases in urinary kallikrein and kinin excretion showed a significant relationship with the consumed plasma fibrinogen levels (r = -0.51, P less than 0.01 and r = -0.58, P less than 0.01, respectively), and it was suggested that activation of the glandular kallikrein-kinin system caused by abrupt DIC-like changes in the hemostatic system might play a role in manifestations of temporary complications occurring with the use of hemostatic agents containing thrombin.
Positive_regulation (activation) of kallikrein in plasma associated with disseminated intravascular coagulation
3) Confidence 0.67 Published 1990 Journal Gastroenterol. Jpn. Section Abstract Doc Link 2227247 Disease Relevance 0.52 Pain Relevance 0.07
In the contact system pathway, C1-inhibitor inactivates both factor XIIa and active kallikrein, thereby preventing both the activation of kallikrein from prekallikrein and the formation of bradykinin, a vascular permeability factor [2,20,21,23-25].
Positive_regulation (activation) of kallikrein associated with bradykinin
4) Confidence 0.45 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.49 Pain Relevance 0.15
The results indicate that increased salivary kallikrein output is associated with the stress response to surgery.
Positive_regulation (increased) of kallikrein associated with stress
5) Confidence 0.45 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9196856 Disease Relevance 0.60 Pain Relevance 0.26
The percentage of total urinary kallikrein in the active form correlated with active kallikrein levels and was also increased in interstitial cystitis patients, particularly those with higher levels of pain.
Positive_regulation (increased) of kallikrein associated with pain and interstitial cystitis
6) Confidence 0.45 Published 1994 Journal J. Urol. Section Abstract Doc Link 8051740 Disease Relevance 0.88 Pain Relevance 0.70
Interstitial cystitis patients had significantly higher levels of kallikrein activity than did the normal volunteers.
Positive_regulation (levels) of kallikrein associated with interstitial cystitis
7) Confidence 0.45 Published 1994 Journal J. Urol. Section Abstract Doc Link 8051740 Disease Relevance 0.87 Pain Relevance 0.69
In the case of 0.9% saline infusion, the activity of renal kallikrein-kinin system is augmented following the infusion as shown in the increases of urinary kallikrein and kinin excretions and the decreases of urinary kininases excretions.
Positive_regulation (increases) of kallikrein
8) Confidence 0.45 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2557757 Disease Relevance 0 Pain Relevance 0.12
Dopamine may augment the activity of the renal kallikrein-kinin system through both the increases of renal prekallikrein synthesis and kallikrein specific activity.
Positive_regulation (increases) of kallikrein associated with dopamine
9) Confidence 0.45 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2557757 Disease Relevance 0 Pain Relevance 0.14
Urinary kallikrein and kinin excretion significantly increased after the procedure (P less than 0.01), indicating activation of the renal kallikrein-kinin system.
Positive_regulation (activation) of kallikrein
10) Confidence 0.45 Published 1990 Journal Gastroenterol. Jpn. Section Abstract Doc Link 2227247 Disease Relevance 0.56 Pain Relevance 0.08
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade.
Positive_regulation (activation) of kallikrein-kinin in plasma associated with pain, hypersensitivity and bradykinin
11) Confidence 0.28 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.29 Pain Relevance 0.23
Effect of Neurotropin on the activation of the plasma kallikrein-kinin system.
Positive_regulation (activation) of kallikrein-kinin in plasma
12) Confidence 0.28 Published 1992 Journal Biochem. Pharmacol. Section Title Doc Link 1562287 Disease Relevance 0.45 Pain Relevance 0.32
Levels of factor XII were reduced in 2 patients who had single factor assays performed, consistent with activation of the kallikrein-kinin system.
Positive_regulation (activation) of kallikrein-kinin
13) Confidence 0.07 Published 2000 Journal Clin. Infect. Dis. Section Abstract Doc Link 10880316 Disease Relevance 0.34 Pain Relevance 0.14
Bradykinin is generated by activation of the plasma kallikrein-kinin (K-K) cascade and contributes to the symptoms of allergic reactions and the perception of pain.
Positive_regulation (activation) of kallikrein-kinin in plasma associated with pain, hypersensitivity and bradykinin
14) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.28 Pain Relevance 0.15
Kallikrein-kinin system activation in streptococcal toxic shock syndrome.
Positive_regulation (activation) of Kallikrein-kinin associated with streptococcus infection
15) Confidence 0.05 Published 2000 Journal Clin. Infect. Dis. Section Title Doc Link 10880316 Disease Relevance 0.36 Pain Relevance 0.12
We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the features of pain, capillary leaking, and severe hypotension characteristic of this syndrome.
Positive_regulation (activation) of kallikrein-kinin in capillary associated with pain, syndrome, cv general 2 under development, bradykinin and septic shock
16) Confidence 0.05 Published 2000 Journal Clin. Infect. Dis. Section Abstract Doc Link 10880316 Disease Relevance 0.55 Pain Relevance 0.15
[Activation of the kallikrein-kinin system by clonidine].
Positive_regulation (Activation) of kallikrein-kinin associated with clonidine
17) Confidence 0.04 Published 1984 Journal Z Gesamte Inn Med Section Title Doc Link 6570395 Disease Relevance 0 Pain Relevance 0.36
Components of the kallikrein-kinin system are activated in response to noxious stimuli (chemical, physical or bacterial), which may lead to excessive release of kinins in the synovial joints that may produce inflammatory joint disease.
Positive_regulation (activated) of kallikrein-kinin in synovial joints associated with inflammation and arthropathy
18) Confidence 0.02 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657626 Disease Relevance 0.42 Pain Relevance 0.26
Furthermore, it is suggested that substances to reduce activation of the kallikrein-kinin system (KKS) may provide a pharmacological basis for the synthesis of novel antirheumatic or anti-inflammatory drugs.
Positive_regulation (activation) of kallikrein-kinin associated with inflammation and cinod
19) Confidence 0.02 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657626 Disease Relevance 0.52 Pain Relevance 0.41
During these operations, the extracorporeal circulation activates kallikrein, which liberates factor XII, complement, plasmin and bradykinin.
Positive_regulation (activates) of kallikrein associated with bradykinin
20) Confidence 0.02 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2287179 Disease Relevance 0.69 Pain Relevance 0.23

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