INT114942

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.65
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1 99.88 Very High Very High Very High
cytokine 107 96.40 Very High Very High Very High
chemokine 23 95.84 Very High Very High Very High
fibrosis 3 93.08 High High
Inflammation 150 90.88 High High
withdrawal 2 79.72 Quite High
antagonist 34 71.88 Quite High
corticosteroid 4 39.44 Quite Low
Inflammatory response 8 23.04 Low Low
agonist 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 456 100.00 Very High Very High Very High
Eosinophilia 22 99.20 Very High Very High Very High
Fibrosis 3 93.08 High High
Aspergillus Infection 44 92.56 High High
INFLAMMATION 158 90.88 High High
Hypersensitivity 45 90.08 High High
Disease 23 82.12 Quite High
Occupational Lung Diseases 32 80.92 Quite High
Injury 36 79.92 Quite High
Metaplasia 6 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree.
Negative_regulation (inhibited) of Positive_regulation (activation) of AhR associated with qutenza
1) Confidence 0.55 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14646185 Disease Relevance 0 Pain Relevance 0.10
Therefore, COX-2 products appear to limit the HDM-induced AHR and play a protective role at the airway functional level.
Negative_regulation (limit) of Positive_regulation (induced) of AHR associated with asthma
2) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.49 Pain Relevance 0.03
We speculate that enhanced SP-D levels may be responsible for an impaired ability of C57BL/6 mice to develop allergen induced AHR.


Negative_regulation (impaired) of Positive_regulation (induced) of AHR
3) Confidence 0.27 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.67 Pain Relevance 0.16
induced AHR was inhibited demonstrating a critical role for FBLN-1 in the mechanism of TGF?
Negative_regulation (inhibited) of Positive_regulation (induced) of AHR
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.60 Pain Relevance 0.08
ASO attenuated allergen-induced AHR, suppressed airway eosinophilia and neutrophilia, and inhibited production of airway Th2 cytokines and chemokines in previously allergen-primed and -challenged mice [198].
Negative_regulation (attenuated) of Positive_regulation (induced) of AHR associated with chemokine, eosinophilia and cytokine
5) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.88 Pain Relevance 0.26

General Comments

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