INT114953

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Context Info
Confidence 0.29
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 31
Disease Relevance 16.58
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
CAR 1
colon 1
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 31 99.04 Very High Very High Very High
agonist 309 98.08 Very High Very High Very High
Inflammation 156 87.92 High High
metalloproteinase 116 85.40 High High
cytokine 59 77.04 Quite High
imagery 5 75.44 Quite High
antagonist 22 66.24 Quite High
Arthritis 24 33.84 Quite Low
diclofenac 1 33.44 Quite Low
COX-2 inhibitor 8 22.44 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 343 99.76 Very High Very High Very High
Carcinoma 149 99.76 Very High Very High Very High
Myeloid Leukemia 56 99.68 Very High Very High Very High
Apoptosis 261 99.20 Very High Very High Very High
Rheumatoid Arthritis 280 99.08 Very High Very High Very High
Leukemia 162 99.08 Very High Very High Very High
INFLAMMATION 184 98.80 Very High Very High Very High
Multiple Myeloma 44 97.68 Very High Very High Very High
Lymphatic System Cancer 70 94.64 High High
Malignant Neoplastic Disease 89 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these dimers, only RXR:PPAR?
Gene_expression (only) of RXR
1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.14 Pain Relevance 0.06
In addition, we document that this inhibition is transcriptionally mediated and involves genetic and epigenetic mechanisms but does not appear to involve competitive binding between RXR:PPAR?
Gene_expression (competitive) of RXR
2) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0
, ligands block MMP-1 and MMP-13 gene expression, RXR:PPAR?
Gene_expression (expression) of RXR
3) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.15 Pain Relevance 0.04
binding to the DR-1/AP-1 site in suppressing MMP-1 and MMP-13 production and addressed possible mechanisms of inhibition, including competitive binding between RXR:PPAR?
Gene_expression (competitive) of RXR
4) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.03
These data may be explained by the fact that, when RXR and PPAR?
Gene_expression (explained) of RXR
5) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
As shown in Figure 9b, no SUMOylated RXR is present in untreated cells or in cells treated with IL-1?
Gene_expression (present) of RXR
6) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0.03
-induced expression of MMP-1 and MMP-13 by combinatorial treatment with RXR and PPAR?
Gene_expression (expression) of RXR
7) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0.17 Pain Relevance 0.12
The presence of RXR and PPAR?
Gene_expression (presence) of RXR
8) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.16 Pain Relevance 0.08
requires a high-level expression of RXR?
Gene_expression (expression) of RXR
9) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25
expression of p-RXR?
Gene_expression (expression) of RXR
10) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.85 Pain Relevance 0
express high levels of p-RXR?
Gene_expression (express) of RXR
11) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.02 Pain Relevance 0.04
in both human HCC tissues and a human HCC cell line, whereas RXR?
Gene_expression (whereas) of RXR associated with carcinoma
12) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.69 Pain Relevance 0
the cooperation of RXR?
Gene_expression (cooperation) of RXR
13) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.27 Pain Relevance 0
Therefore, the activation of the RXR/PPAR?
Gene_expression (/) of RXR
14) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.80 Pain Relevance 0.25
These findings suggest that RXR?
Spec (suggest) Gene_expression (suggest) of RXR
15) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.40 Pain Relevance 0
A malfunction of RXR?
Gene_expression (malfunction) of RXR
16) Confidence 0.22 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2408709 Disease Relevance 0.47 Pain Relevance 0
for both RXR and RAR [34, 35], can restore the function of RXR?
Gene_expression (function) of RXR
17) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.56 Pain Relevance 0.05
/RXR-dependent
Gene_expression (dependent) of RXR
18) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.22 Pain Relevance 0.12
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Gene_expression (expression) of RXR associated with agonist
19) Confidence 0.11 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.54
Thus, on DR3 and DR5, RXR occupies the 5?
Gene_expression (occupies) of RXR
20) Confidence 0.05 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0

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