INT114955

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREBBP) small molecule metabolic process (CREBBP) protein complex assembly (CREBBP)
DNA binding (CREBBP) cytoplasm (CREBBP) signal transducer activity (CREBBP)
CREBBP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 99.56 Very High Very High Very High
cINOD 7 89.16 High High
antagonist 4 70.72 Quite High
diclofenac 1 37.92 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 88.60 High High
Repression 4 15.44 Low Low
Disease 10 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Asthma 3 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Nasal Polyps 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Positive_regulation (enhanced) of Gene_expression (co-expression) of CBP associated with agonist
1) Confidence 0.23 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.61
For example, overexpression of CBP has been shown to prevent the inhibition of hPPAR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of CBP
2) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0

General Comments

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