INT114957

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 10.36
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 143 99.78 Very High Very High Very High
Inflammation 206 96.92 Very High Very High Very High
Bile 32 96.64 Very High Very High Very High
cytokine 49 93.88 High High
dexamethasone 14 93.76 High High
Inflammatory response 27 89.68 High High
cINOD 16 86.24 High High
antagonist 13 78.24 Quite High
rheumatoid arthritis 66 64.92 Quite High
aspirin 18 57.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 240 96.92 Very High Very High Very High
Stress 39 96.60 Very High Very High Very High
Obesity 236 96.28 Very High Very High Very High
Hepatotoxicity 10 93.52 High High
Diabetes Mellitus 146 92.60 High High
Colorectal Cancer 23 89.64 High High
Atherosclerosis 54 87.72 High High
Van Bogaert's Disease 12 86.16 High High
Cancer 129 85.92 High High
Targeted Disruption 17 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This results in transcription of PPAR?
Positive_regulation (results) of Transcription (transcription) of PPAR
1) Confidence 0.62 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.71 Pain Relevance 0.07
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Positive_regulation (activation) of Transcription (transcription) of PPAR associated with agonist
2) Confidence 0.47 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.63
11-week pioglitazone treatment, unlike the increases observed for the transcript levels of the established PPAR?
Positive_regulation (increases) of Transcription (levels) of PPAR
3) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.47 Pain Relevance 0.04
Stimulated mRNA expression of uncoupling protein 2 (Ucp2) by PPAR?
Positive_regulation (Stimulated) of Transcription (expression) of PPAR
4) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.97 Pain Relevance 0.10
Stimulated mRNA expression of uncoupling protein 2 (Ucp2) by PPAR?
Positive_regulation (by) of Transcription (expression) of PPAR
5) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.96 Pain Relevance 0.10
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (peroxisome) of Transcription (transcription) of PPAR
6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.80 Pain Relevance 0.34
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (regulatory) of Transcription (transcription) of PPAR
7) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.81 Pain Relevance 0.34
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (activating) of Transcription (transcription) of PPAR
8) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.82 Pain Relevance 0.34
Some reports suggest a transcriptional upregulation of Cyp7a1 upon PPAR?
Positive_regulation (upregulation) of Transcription (transcriptional) of PPAR
9) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.45 Pain Relevance 0.23
Some reports suggest a transcriptional upregulation of Cyp7a1 upon PPAR?
Positive_regulation (upon) of Transcription (transcriptional) of PPAR
10) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.45 Pain Relevance 0.23
corepressor complexes resulting in transcription of PPAR?
Positive_regulation (resulting) of Transcription (transcription) of PPAR
11) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.44 Pain Relevance 0.18
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (peroxisome) of Transcription (transcription) of proliferator-activated receptor
12) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.80 Pain Relevance 0.33
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (activating) of Transcription (transcription) of proliferator-activated receptor
13) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.82 Pain Relevance 0.34
IL4 induces the expression of CD36 by activating the regulatory transcription factor peroxisome proliferator-activated receptor (PPAR)?
Positive_regulation (regulatory) of Transcription (transcription) of proliferator-activated receptor
14) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.81 Pain Relevance 0.34
Thus, our findings in human tissue are compatible with the in vitro studies about the transcriptional induction of PPAR?
Positive_regulation (induction) of Transcription (transcriptional) of PPAR
15) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.46 Pain Relevance 0
and storage, which increased the transcriptional activity of PPAR?
Positive_regulation (increased) of Transcription (transcriptional) of PPAR
16) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.17 Pain Relevance 0
and storage, which increased the transcriptional activity of PPAR?
Positive_regulation (increased) of Transcription (activity) of PPAR
17) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.17 Pain Relevance 0
We firmly believe that combining a sequencing-based ChIP assay to high-throughput transcriptome analysis by RNA-Seq on NGS platforms, above all for inducible transcription factors (and PPAR?
Positive_regulation (inducible) of Transcription (transcription) of PPAR
18) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0 Pain Relevance 0.05

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