INT11496

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.41
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
plasma membrane (F12)
Anatomy Link Frequency
plasma 2
cleavage 1
hypopharynx 1
F12 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 43 99.04 Very High Very High Very High
anesthesia 2 92.60 High High
antagonist 11 89.36 High High
b2 receptor 16 88.72 High High
B1 receptor 4 84.96 Quite High
Pain 14 77.08 Quite High
Angina 6 50.00 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 97.32 Very High Very High Very High
Hereditary Angioedema 229 95.64 Very High Very High Very High
Edema 102 93.32 High High
Cv General 3 Under Development 6 90.80 High High
Hemorrhage 5 87.00 High High
Pox Virus Infection 1 84.44 Quite High
Disease 12 84.28 Quite High
Pressure Volume 2 Under Development 5 83.76 Quite High
Pressure And Volume Under Development 6 80.48 Quite High
Pain 16 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Anesthetic management of a patient with deficiency of congenital coagulation factor XII].
Negative_regulation (deficiency) of coagulation factor XII
1) Confidence 0.59 Published 2003 Journal Masui Section Title Doc Link 13677286 Disease Relevance 0.27 Pain Relevance 0.09
A 63-year-old man with deficiency of congenital coagulation factor XII, was referred to our hospital for an operation of the hypopharynx cancer.
Negative_regulation (deficiency) of coagulation factor XII in hypopharynx associated with cancer
2) Confidence 0.59 Published 2003 Journal Masui Section Abstract Doc Link 13677286 Disease Relevance 0.25 Pain Relevance 0.09
In dextran sulfate-activated plasma, Neurotropin inhibited the formation of BK, the cleavage of high molecular weight kininogen (HK) and the formation of kallikrein-C1 inhibitor and activated coagulation factor XII (FXIIa)-C1 inhibitor complexes.
Negative_regulation (inhibitor) of coagulation factor XII in cleavage associated with bradykinin
3) Confidence 0.36 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.44 Pain Relevance 0.30
C1-inh is also a major inhibitor of factor XII and kallikrein of the contact system, and to a lesser extent of factor XI and tissue-type plasminogen.
Negative_regulation (inhibitor) of factor XII
4) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2887436 Disease Relevance 0.70 Pain Relevance 0.04
METHODS AND RESULTS: We determined serially in the patients up to 10 days after admission factor XII and the beta-factor XIIa inhibition, kallikrein-like activity, prekallikrein, C1-esterase inhibitor, kallikrein inhibition, high molecular weight kininogen as indicators of the contact phase and bradykinin generation, thrombin-antithrombin III (TAT) complex as marker of the activated coagulation cascade, fibrinogen, plasminogen, plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (TPA), and D-dimers as indicators of the fibrinolytic system.
Negative_regulation (inhibition) of beta-factor XIIa
5) Confidence 0.02 Published 1995 Journal Circulation Section Body Doc Link 7743613 Disease Relevance 0.18 Pain Relevance 0
Like strategies targeting plasma kallikrein, inhibition of factor XII activity might prevent bradykinin generation [80].
Negative_regulation (inhibition) of factor XII in plasma associated with bradykinin
6) Confidence 0.01 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.49 Pain Relevance 0.44
Replacement therapy with C1INH will inhibit both plasma kallikrein and activated factor XII.
Negative_regulation (inhibit) of factor XII in plasma
7) Confidence 0.01 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.08 Pain Relevance 0.31

General Comments

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