INT114961

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.55
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
CAR 2
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 99.92 Very High Very High Very High
agonist 78 99.56 Very High Very High Very High
Inflammation 17 87.92 High High
imagery 2 71.24 Quite High
antagonist 4 70.72 Quite High
diclofenac 1 37.92 Quite Low
COX-2 inhibitor 2 18.24 Low Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.68 Very High Very High Very High
Rheumatoid Arthritis 51 96.36 Very High Very High Very High
Colon Cancer 83 96.20 Very High Very High Very High
Malignant Neoplastic Disease 17 88.80 High High
Cancer 186 87.92 High High
Skin Cancer 10 84.52 Quite High
Colitis 4 84.48 Quite High
Lymphatic System Cancer 3 84.08 Quite High
Disease Progression 5 73.32 Quite High
Disease 33 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the activation of the RXR/PPAR?
Positive_regulation (activation) of Gene_expression (/) of RXR
1) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25
requires a high-level expression of RXR?
Positive_regulation (requires) of Gene_expression (expression) of RXR
2) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25
the cooperation of RXR?
Positive_regulation (cooperation) of Gene_expression (cooperation) of RXR
3) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.27 Pain Relevance 0
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Positive_regulation (enhanced) of Gene_expression (expression) of RXR associated with agonist
4) Confidence 0.07 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.61
To investigate DNA binding of CAR variant proteins to response elements in the XREM of CYP3A4 [17] and in the -7.8 kb enhancer of MDR1 (Burk et al., to be published elsewhere), we performed electrophoretic mobility shift assays using in vitro translated RXR?
Positive_regulation (translated) of Gene_expression (translated) of RXR in CAR
5) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
Treatment with RXR
Positive_regulation (Treatment) of Gene_expression (with) of RXR
6) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 1.42 Pain Relevance 0.08

General Comments

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