INT114964

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gpx1) aging (Gpx1) lipid metabolic process (Gpx1)
cytoplasm (Gpx1) cytosol (Gpx1) cell proliferation (Gpx1)
Anatomy Link Frequency
embryos 4
Gpx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 50.00 Quite Low
Analgesic 3 50.00 Quite Low
aspirin 2 10.00 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 32 99.90 Very High Very High Very High
Diabetes Mellitus 200 99.04 Very High Very High Very High
Exencephaly /

Neural Tube Defects

8 96.28 Very High Very High Very High
Apoptosis 40 94.08 High High
Gestational Diabetes 36 93.72 High High
Parkinson's Disease 4 93.32 High High
Stress 20 7.84 Low Low
Fetal Diseases 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further efforts in the search for the etiology of diabetes-induced congenital malformations may therefore benefit from considering a putative impact of a decrease in embryonic Gpx-1 expression and, possibly, function as well as considering the importance of enhanced VEGF-A expression for embryonic development.
Negative_regulation (decrease) of Gene_expression (expression) of Gpx-1 associated with diabetes mellitus
1) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.54 Pain Relevance 0
Evidently, however, the association between malformation and reduced Gpx-1 expression may also be the opposite; the embryonic maldevelopment may actually induce the alteration in Gpx-1 mRNA levels and, putatively, decreased activity of the enzyme (7).
Negative_regulation (reduced) of Gene_expression (expression) of Gpx-1 associated with congenital anomalies
2) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.63 Pain Relevance 0
A simultaneous injection of antioxidants decreased the levels of TBARS, SOD and GSHPx; however, antioxidants applied one week prior to the painful stimulation were ineffective.
Negative_regulation (decreased) of Gene_expression (levels) of GSHPx
3) Confidence 0.40 Published 2003 Journal Neuro Endocrinol. Lett. Section Body Doc Link 14647001 Disease Relevance 0 Pain Relevance 0
We found decreased gene expression of Gpx-1 and increased expression of vascular endothelial growth factor-A (Vegf-A) in malformed embryos of diabetic rats (MDm group) compared with nonmalformed littermates (MDn group).
Negative_regulation (decreased) of Gene_expression (expression) of Gpx-1 in embryos associated with diabetes mellitus
4) Confidence 0.39 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.60 Pain Relevance 0
The specific decrease in Gpx-1 expression/occurrence in MDm embryos may suggest an association between the abundance of this isoform of glutathione peroxidase and the teratogenicity of diabetes, tentatively, with the processes behind cardiac malformations.
Negative_regulation (decrease) of Gene_expression (expression) of Gpx-1 in embryos associated with diabetes mellitus
5) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.46 Pain Relevance 0

General Comments

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