INT114965

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.82
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gpx1) aging (Gpx1) lipid metabolic process (Gpx1)
cytoplasm (Gpx1) cytosol (Gpx1) cell proliferation (Gpx1)
Anatomy Link Frequency
embryos 5
heart 3
mandible 1
testis 1
first visceral arch 1
Gpx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 9 100.00 Very High Very High Very High
Pain 4 50.00 Quite Low
Analgesic 3 50.00 Quite Low
Morphine 3 50.00 Quite Low
Inflammation 20 44.64 Quite Low
aspirin 2 10.00 Low Low
Kinase C 20 5.00 Very Low Very Low Very Low
Potency 11 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 44 100.00 Very High Very High Very High
Coronary Artery Disease 7 100.00 Very High Very High Very High
Reperfusion Injury 2 100.00 Very High Very High Very High
Diabetes Mellitus 635 99.84 Very High Very High Very High
Apoptosis 102 98.94 Very High Very High Very High
Congenital Anomalies 82 96.72 Very High Very High Very High
Exencephaly /

Neural Tube Defects

20 96.28 Very High Very High Very High
Stress 91 92.20 High High
Gestational Diabetes 90 91.72 High High
Arrhythmias 2 Under Development 1 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, enhanced apoptosis of the first visceral arch and heart, together with decreased cardiac Gpx-1 levels, may cause the mandible and heart to have an increased risk of developing congenital malformation.


Negative_regulation (decreased) of Gpx-1 in first visceral arch associated with congenital anomalies and apoptosis
1) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0
The effect on AOE gene expression was strikingly similar in CuZnSOD, MnSOD, and Gpx-1, which were all decreased.
Negative_regulation (decreased) of Gpx-1
2) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
The Gpx-1 mRNA was markedly decreased and the VEGF-A mRNA was markedly increased in malformed compared with nonmalformed embryos from the same litter of diabetic rats.
Negative_regulation (decreased) of Gpx-1 in embryos associated with diabetes mellitus
3) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.44 Pain Relevance 0
In particular, enhanced apoptosis of the first visceral arch and heart, together with decreased cardiac Gpx-1 levels, may compromise the mandible and heart and thus cause an increased risk of developing congenital malformation.



Negative_regulation (decreased) of Gpx-1 in mandible associated with congenital anomalies and apoptosis
4) Confidence 0.39 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
In addition, Gpx-1 mRNA levels were more decreased in MDm than in MDn embryos, and Gpx-2 and catalase expression did not differ between the groups (Fig. 2).
Negative_regulation (decreased) of Gpx-1 in embryos
5) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.41 Pain Relevance 0
In addition, in the present study we detected decreased Gpx-1 mRNA levels in MDm embryos and a corresponding reduction of Gpx-1 protein in the cardiac tissues of the MDm embryos, both findings differing from MDn embryos of the same litters, as well as from Gpx-1 estimations in N embryos.
Negative_regulation (decreased) of Gpx-1 in embryos
6) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.39 Pain Relevance 0
In addition, in the present study we detected decreased Gpx-1 mRNA levels in MDm embryos and a corresponding reduction of Gpx-1 protein in the cardiac tissues of the MDm embryos, both findings differing from MDn embryos of the same litters, as well as from Gpx-1 estimations in N embryos.
Negative_regulation (reduction) of Gpx-1 in embryos
7) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.39 Pain Relevance 0
The specific decrease in Gpx-1 expression/occurrence in MDm embryos may suggest an association between the abundance of this isoform of glutathione peroxidase and the teratogenicity of diabetes, tentatively, with the processes behind cardiac malformations.
Negative_regulation (decrease) of Gpx-1 in embryos associated with diabetes mellitus
8) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.41 Pain Relevance 0
CONCLUSION: Morphine dependence can induce testis cell apoptosis, an increase in testis NOS positive cells, a decrease in CaM content and the activity of SOD and GSHPx in the testis.
Negative_regulation (decrease) of GSHPx in testis
9) Confidence 0.38 Published 2004 Journal Zhonghua Nan Ke Xue Section Body Doc Link 15595686 Disease Relevance 0 Pain Relevance 0
A simultaneous injection of antioxidants decreased the levels of TBARS, SOD and GSHPx; however, antioxidants applied one week prior to the painful stimulation were ineffective.
Negative_regulation (decreased) of GSHPx
10) Confidence 0.29 Published 2003 Journal Neuro Endocrinol. Lett. Section Body Doc Link 14647001 Disease Relevance 0 Pain Relevance 0
In particular, enhanced apoptosis of the first visceral arch and heart, together with decreased cardiac Gpx-1 levels, may cause the mandible and heart to have an increased risk of developing congenital malformation.


Negative_regulation (decreased) of Gpx-1 in heart associated with congenital anomalies and apoptosis
11) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0
In particular, enhanced apoptosis of the first visceral arch and heart, together with decreased cardiac Gpx-1 levels, may compromise the mandible and heart and thus cause an increased risk of developing congenital malformation.



Negative_regulation (decreased) of Gpx-1 in heart associated with congenital anomalies and apoptosis
12) Confidence 0.13 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
GSHPx, an important defense mechanism against not only myocardial ischemia/reperfusion injury [91] but also post-MI cardiac failure [92], has been reported to be markedly decreased in diabetic coronary heart disease patients [93].
Negative_regulation (decreased) of GSHPx in heart associated with reperfusion injury, coronary artery disease, diabetes mellitus, ischemia and myocardial infarction
13) Confidence 0.08 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801857 Disease Relevance 1.81 Pain Relevance 0.14

General Comments

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