INT114993

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 11.46
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Anatomy Link Frequency
lungs 2
T cells 1
Myo5a (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 90 100.00 Very High Very High Very High
cva 3 99.16 Very High Very High Very High
headache 8 90.64 High High
Pain 10 88.04 High High
cytokine 20 84.08 Quite High
Angina 4 50.00 Quite Low
corticosteroid 1 6.32 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 169 100.00 Very High Very High Very High
Mevalonate Kinase Deficiency 38 100.00 Very High Very High Very High
Coronary Heart Disease 2 99.76 Very High Very High Very High
Cicatrix 25 99.68 Very High Very High Very High
Cv General 3 Under Development 4 99.16 Very High Very High Very High
Disease 49 98.88 Very High Very High Very High
Infection 336 98.16 Very High Very High Very High
Trepenoma Infection 1 97.44 Very High Very High Very High
Severe Combined Immunodeficiency 72 97.24 Very High Very High Very High
Sprains And Strains 246 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the vast majority of the studies, the prevalence percentages for an opioid association with MVA fatalities was 1/5 that of the point prevalence percentage for opioid use reported in the general population.
MVA Binding (association) of associated with opioid
1) Confidence 0.30 Published 2002 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 14650448 Disease Relevance 0 Pain Relevance 0.97
Only 1 study reported a possible association between opioid use and MVA fatalities.
MVA Binding (association) of associated with opioid
2) Confidence 0.30 Published 2002 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 14650448 Disease Relevance 0 Pain Relevance 0.99
Overall, the evidence indicates that opioids are not associated with MVA.
MVA Binding (associated) of associated with opioid
3) Confidence 0.30 Published 2002 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 14650448 Disease Relevance 0 Pain Relevance 0.97
All reports in this group except one indicated that opioids are not associated with MVA.
MVA Binding (associated) of associated with opioid
4) Confidence 0.30 Published 2002 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 14650448 Disease Relevance 0 Pain Relevance 1.04
The evidence in this review indicates that opioids do not appear to be associated with intoxicated driving, MVA and MVA fatalities, and consistently indicated that opioids are not associated with MVA.
MVA Binding (associated) of associated with opioid
5) Confidence 0.30 Published 2002 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 14650448 Disease Relevance 0 Pain Relevance 0.95
In the present study, we showed that a single immunization with MVA-HA-VN/04 protected mice from severe disease caused by infection with the homologous strain or the A/Indonesia/5/05 strain, especially when a high dose (108 pfu) was used.
MVA-HA-VN/04 Binding (immunization) of associated with immunization, sprains and strains, disease and infection
6) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 1.17 Pain Relevance 0
Two immunizations with MVA-HA-VN/04 afforded cross-clade protection.
MVA-HA-VN/04 Binding (immunizations) of
7) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.17 Pain Relevance 0
The mean virus titer in mice immunized once with 103 pfu of MVA-HA-VN/04 was 107.5 (SD?
MVA-HA-VN/04 Binding (pfu) of
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 1.15 Pain Relevance 0
Mice that received a single immunization with 104 or 105 pfu MVA-HA-VN/04, and those vaccinated twice with 103 pfu, developed mild clinical signs after infection with the homologous influenza virus A/VN/1194/04.
MVA-HA-VN/04 Binding (immunization) of associated with influenza virus infection, immunization and infection
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 1.45 Pain Relevance 0
In contrast to two immunizations, it was not possible to induce sterilizing immunity after a single immunization with MVA-HA-VN/04.
MVA-HA-VN/04 Spec (possible) Binding (immunization) of associated with immunization
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.95 Pain Relevance 0
secreting CD8 T-cells can be detected only after 5 days in the lungs [35] whereas, after immunization with MVA-H1, they are present already in high frequencies before infection, and, upon infection, enter the lungs much more rapidly by relocation from other sites such as the spleen.
MVA-H1 Binding (immunization) of in lungs associated with immunization and infection
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.09 Pain Relevance 0.03
secretion in mice immunized with both the MVA and the VVL-based HA constructs.
MVA Binding (immunized) of
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.27 Pain Relevance 0.03
Balb/c mice vaccinated with the MVA-H1-Ca virus or the inactivated vaccine were fully protected from lung infection after challenge with the influenza H1N1 wild-type strain, while the neuraminidase virus MVA-N1-Ca induced only partial protection.
MVA-H1 Binding (vaccinated) of in lung associated with influenza virus infection, sprains and strains and infection
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2922371 Disease Relevance 1.07 Pain Relevance 0
Specific induction of 0.5–0.8% of CD4 T cells was seen after homologous stimulation with H1N1/CA antigen of splenocytes of mice vaccinated with the MVA and VVL-based vaccines.
MVA Binding (vaccinated) of in T cells
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.35 Pain Relevance 0.04
Immunogenicity of MVA85A in BCG Scar negative vaccinees
MVA85A Binding (Immunogenicity) of associated with cicatrix
15) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.97 Pain Relevance 0.21
CONCLUSIONS: There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.


MVA Binding (association) of
16) Confidence 0.04 Published 2005 Journal Circ. J. Section Body Doc Link 16308493 Disease Relevance 0.06 Pain Relevance 0
Since vaccination with MVA causes a characteristic local reactogenicity in some subjects, specific steps were taken to ensure that the participants were evaluated in a double-blinded manner.
MVA Binding (vaccination) of
17) Confidence 0.03 Published 2004 Journal PLoS Medicine Section Body Doc Link PMC524376 Disease Relevance 0.63 Pain Relevance 0.18
As MVA is an autosomal recessive disorder, the risk for future pregnancies is 25% for families who already have a child with MVA.
MVA Binding (child) of associated with mevalonate kinase deficiency
18) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 0.63 Pain Relevance 0
Although MVA has not been associated with myocarditis or pericarditis to date, due to the rare occurrence of cardiac events after vaccination with live replicating vaccinia to prevent smallpox infection [12], [13], volunteers with abnormal electrocardiograms, troponin values, or a history of cardiac abnormalities were also excluded from this study.
MVA Binding (associated) of associated with pox virus infection, cva, coronary heart disease, cardiovascular disorder under development and infection
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810329 Disease Relevance 1.49 Pain Relevance 0.05

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