INT115

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 16.27
Pain Relevance 38.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 16
liver 3
striatum 2
5-HT neurons 2
plasma 1
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 328 100.00 Very High Very High Very High
antidepressant 509 99.98 Very High Very High Very High
Dopamine 587 99.92 Very High Very High Very High
butorphanol 8 99.86 Very High Very High Very High
Clonidine 13 99.84 Very High Very High Very High
antinociception 10 99.80 Very High Very High Very High
Analgesic 41 99.72 Very High Very High Very High
Pain 12 99.70 Very High Very High Very High
analgesia 10 99.60 Very High Very High Very High
methadone 23 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.80 Very High Very High Very High
Nicotine Addiction 350 99.68 Very High Very High Very High
Anxiety Disorder 15 99.56 Very High Very High Very High
Schizophrenia 40 99.40 Very High Very High Very High
Parkinson's Disease 31 99.36 Very High Very High Very High
Toxicity 10 99.20 Very High Very High Very High
Alzheimer's Dementia 116 99.16 Very High Very High Very High
Disease 350 98.68 Very High Very High Very High
Aggression 278 98.52 Very High Very High Very High
Convulsion 13 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that clorgyline showed an inhibitory effect on morphine-induced hyperlocomotion, but not antinociception, through MAO inhibition.
Negative_regulation (inhibition) of MAO associated with antinociception and morphine
1) Confidence 0.59 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16794857 Disease Relevance 0 Pain Relevance 1.45
Methadone also produced a 60% inhibition of the MAO activity of the hippocampus, a 32% inhibition of the striatal and hypothalamic enzyme, a 30% inhibition of liver, and a 20 and 23% inhibition of the cerebral cortex and cerebellum, respectively.
Negative_regulation (inhibition) of MAO in hippocampus associated with hippocampus, methadone and cerebral cortex
2) Confidence 0.59 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 432429 Disease Relevance 0 Pain Relevance 1.07
[The effect of monoamine oxidase inhibition on formation, fixation and reproduction of temporary connections].
Negative_regulation (inhibition) of monoamine oxidase associated with pain and monoamine
3) Confidence 0.58 Published 1975 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Title Doc Link 1210682 Disease Relevance 0 Pain Relevance 0.27
Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons.
Negative_regulation (Inhibition) of monoamine oxidase in 5-hydroxytryptamine neurons associated with monoamine
4) Confidence 0.58 Published 1991 Journal Neuropharmacology Section Title Doc Link 1852266 Disease Relevance 0 Pain Relevance 0.11
Because tobacco smoke contains monoamine oxidase inhibitors (MAOIs) and decreases MAO activity in smokers, we have combined MAOIs with nicotine to determine whether it is possible to obtain a locomotor response to nicotine in C57Bl6 mice.
Negative_regulation (decreases) of MAO associated with nicotine addiction, nicotine and monoamine
5) Confidence 0.58 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16395299 Disease Relevance 0.25 Pain Relevance 0.63
Among 15 individual or combined MAOIs, including harmane, norharmane, moclobemide, selegiline, pargyline, clorgyline, tranylcypromine and phenelzine, only irreversible inhibitors of both MAO-A and -B (tranylcypromine, phenelzine, and clorgyline+selegiline) allowed a locomotor response to nicotine.
Negative_regulation (inhibitors) of MAO associated with nicotine
6) Confidence 0.58 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16395299 Disease Relevance 0.25 Pain Relevance 0.69
The effectiveness of the MAO inhibitors in blocking the action of the reduced toxins was consistent with their ability to inhibit MAO activity in the cell cultures, but did not reflect MAO-substrate specificity of the toxins.
Negative_regulation (inhibit) of MAO
7) Confidence 0.58 Published 1991 Journal Mol. Chem. Neuropathol. Section Abstract Doc Link 1776993 Disease Relevance 0.81 Pain Relevance 0.31
The present study shows that MAO activity was inhibited during smoking and restored after quitting, whereas MAO protein concentration was increased during smoking and remained high for many years after quitting.
Negative_regulation (inhibited) of MAO associated with nicotine addiction
8) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.22 Pain Relevance 0.04
Pertinent results obtained are delineated below: 1) DFZ at 10(-4) M inhibited the monoamine oxidase (MAO) activity to some extent although it had no activity on catechol-O-methyltransferase (COMT) at 10(-6) -10(-4) M. 2) DFZ significantly enhanced the DA accumulating activity of pargyline in the striatum. 3) DFZ inhibited the binding of 3H-DA to synaptic membrane by 25% at 10(-4) M in the striatum. 4) DFZ inhibited the DA uptake by 50% at 10(-4) M though the activity was somewhat weaker than imipramine or cocaine on the striatum. 5) DFZ inhibited the DA release due to high K+ concentration in striatal slices at 10(-4) -5x10(-4) M.
Negative_regulation (inhibited) of monoamine oxidase in striatum associated with catechol-o-methyltransferase, dopamine, cocaine and monoamine
9) Confidence 0.57 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6454942 Disease Relevance 0 Pain Relevance 0.80
Pertinent results obtained are delineated below: 1) DFZ at 10(-4) M inhibited the monoamine oxidase (MAO) activity to some extent although it had no activity on catechol-O-methyltransferase (COMT) at 10(-6) -10(-4) M. 2) DFZ significantly enhanced the DA accumulating activity of pargyline in the striatum. 3) DFZ inhibited the binding of 3H-DA to synaptic membrane by 25% at 10(-4) M in the striatum. 4) DFZ inhibited the DA uptake by 50% at 10(-4) M though the activity was somewhat weaker than imipramine or cocaine on the striatum. 5) DFZ inhibited the DA release due to high K+ concentration in striatal slices at 10(-4) -5x10(-4) M.
Negative_regulation (inhibited) of MAO in striatum associated with catechol-o-methyltransferase, dopamine, cocaine and monoamine
10) Confidence 0.57 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6454942 Disease Relevance 0 Pain Relevance 0.80
The results suggest that the HTR induced by 5- and 6-FMT may result from increased activity of central 5-HT neurons, probably due to increased 5-HT levels after MAO-A inhibition.
Negative_regulation (inhibition) of MAO-A in 5-HT neurons
11) Confidence 0.57 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617148 Disease Relevance 0 Pain Relevance 0.16
The present results also indicate the importance of the methyl group to selective MAO-A inhibition by the substrate-analogues tested, and the concomitantly induced animal behavior.
Negative_regulation (inhibition) of MAO-A
12) Confidence 0.57 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7617148 Disease Relevance 0 Pain Relevance 0.14
As such, inhibitors of COMT lead to dramatic decreases in 3-MT levels while blockade of MAO induces remarkable elevations in 3-MT levels [35], [38], [50], [52].
Negative_regulation (blockade) of MAO
13) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.70 Pain Relevance 0.26
Various intraperitoneal doses of 5-fluoro-alpha-methyltryptamine (5-FMT), given to mice, dose-dependently inhibited only MAOA activity, with similar degrees of inhibition in the striatum, hypothalamus and the rest of the forebrain.
Negative_regulation (inhibited) of MAOA in forebrain
14) Confidence 0.51 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1852266 Disease Relevance 0 Pain Relevance 0.04
In fact, numerous studies have been performed on the analysis of DA release in various experimental paradigms by assessing accumulation of 3-MT tissue levels in brain tissue, often after blockade of MAO by pargyline [7], [38].
Negative_regulation (blockade) of MAO in brain associated with dopamine
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.05 Pain Relevance 0.55
Thus, antidepressant-like activity of the extract might also be due to inhibition of MAO, resulting in increase in the brain levels of monoamines.
Negative_regulation (inhibition) of MAO in brain associated with antidepressant and monoamine
16) Confidence 0.45 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0.06 Pain Relevance 0.84
The most notable of MAOA polymorphism was a nonsense mutation that led to a complete loss of MAOA function in males showing extreme forms of impulsive behavior and aggression [65].
Negative_regulation (loss) of MAOA associated with aggression
17) Confidence 0.44 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.77 Pain Relevance 0.32
Both methadone and levorphanol produced a concentration-dependent inhibition of whole brain mitochondrial MAO in vitro with an IC50 of approximately 7.4 x 10(-4) for levorphanol and 2.5 x 10(-6)M for methadone.
Negative_regulation (inhibition) of MAO in brain associated with methadone
18) Confidence 0.43 Published 1979 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 432429 Disease Relevance 0 Pain Relevance 0.86
To study the role of dopamine (DA) in antidepressant-like effect in the forced swimming test (FST), the relationship between the magnitude of the antidepressant-like effect of drugs [citalopram, fluoxetine, paroxetine (selective serotonin reuptake inhibitors), desipramine (tricyclic antidepressant), maprotiline (tetracyclic antidepressant), bupropion (DA reuptake inhibitor), and tranylcypromine (inhibitor of monoamine oxidase)] and the corresponding concentration of DA in the whole brain of mice was investigated.
Negative_regulation (inhibitor) of monoamine oxidase in brain associated with desipramine, antidepressant, dopamine, tricyclic antidepressant, ssri, monoamine and fluoxetine
19) Confidence 0.43 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15588751 Disease Relevance 0 Pain Relevance 0.95
Interaction of butorphanol, with monoamine oxidase inhibitor, tranylcypromine.
Negative_regulation (inhibitor) of monoamine oxidase associated with butorphanol and monoamine
20) Confidence 0.43 Published 1991 Journal Forensic Sci. Int. Section Title Doc Link 1855717 Disease Relevance 0.20 Pain Relevance 1.27

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