INT115039

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FMR1) transport (FMR1) mRNA binding (FMR1)
nucleolus (FMR1) RNA binding (FMR1) nucleus (FMR1)
Anatomy Link Frequency
blood 1
liver 1
FMR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 99.14 Very High Very High Very High
Paracetamol 3 98.96 Very High Very High Very High
abdominal pain 2 96.08 Very High Very High Very High
Central nervous system 1 95.58 Very High Very High Very High
backache 1 30.64 Quite Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Ovarian Failure 12 100.00 Very High Very High Very High
Acute Renal Failure 5 100.00 Very High Very High Very High
Acute Liver Failure 5 100.00 Very High Very High Very High
Toxicity 2 99.14 Very High Very High Very High
Neurodegenerative Disease 2 98.80 Very High Very High Very High
Metabolic Disorder 1 98.00 Very High Very High Very High
Retts Disease 1 97.20 Very High Very High Very High
Injury 1 96.16 Very High Very High Very High
Abdominal Pain 2 96.08 Very High Very High Very High
Central Nervous System Infection 1 95.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with unexplained DD/MR were defined as those without etiological diagnosis after thorough clinical evaluations, and were included based on the following criteria: 1) moderate to severe DD/MR (IQ < 55, assessed with Gesell Developmental Schedules or Wechsler intelligence scale for children); 2) definite exclusion of perinatal brain injury; 3) no history of toxication, hypoxia, central nervous system infection and cranial trauma; 4) normal routine karyotyping; 5) no evidence of recognizable inherited metabolic disorder or specific neurodegenerative disorders by brain imaging and blood/urinary metabolic screening; 6) negative for mutations in the FMR1 gene for male patients; 7) negative for typical clinical features of Rett syndrome for female patients.
Positive_regulation (negative) of FMR1 in blood associated with intellectual impairment, hypoxia, metabolic disorder, injury, retts disease, central nervous system, imagery, neurodegenerative disease and brain injury
1) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.77 Pain Relevance 0.10
Scientific literature suggests that genes interruption is not the major cause of pathological phenotype [9], in particular the breakpoint could cause POF through modification of long-range transcriptional regulative control, modifying the expression of genes flanking the breakpoint [10].
Positive_regulation (cause) of POF associated with premature ovarian failure
2) Confidence 0.24 Published 2009 Journal Mol Cytogenet Section Body Doc Link PMC2761935 Disease Relevance 0.26 Pain Relevance 0
Familial renal hypouricemia with exercise-induced acute renal failure (ARF) is rare.
Positive_regulation (induced) of acute renal failure associated with acute renal failure
3) Confidence 0.02 Published 2003 Journal Am. J. Kidney Dis. Section Abstract Doc Link 14655203 Disease Relevance 0.77 Pain Relevance 0.10
BACKGROUND &amp; AIMS: Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings.
Positive_regulation (cause) of acute liver failure in liver associated with toxicity, paracetamol and acute liver failure
4) Confidence 0.00 Published 2006 Journal Gastroenterology Section Abstract Doc Link 16530510 Disease Relevance 0.46 Pain Relevance 0.27

General Comments

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