INT115042

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gdnf, Calca) extracellular region (Gdnf, Calca) cell proliferation (Gdnf)
aging (Calca) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
outflow 1
glial cell 1
Gdnf (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 109 100.00 Very High Very High Very High
qutenza 52 100.00 Very High Very High Very High
Nerve growth factor 104 93.68 High High
Spinal cord 4 87.80 High High
nociceptor 6 51.80 Quite High
Neuropeptide 11 50.00 Quite Low
Trigeminal ganglion neurons 1 50.00 Quite Low
Pain 5 48.72 Quite Low
trigeminal ganglion 59 5.00 Very Low Very Low Very Low
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 9 86.60 High High
Increased Venous Pressure Under Development 1 85.68 High High
Hypertrophy 1 76.16 Quite High
Ganglion Cysts 73 50.00 Quite Low
Pain 5 48.72 Quite Low
Injury 23 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As both sensory and motoneurons express receptors for glial cell line-derived neurotrophic factor (GDNF) we sought to determine whether CGRP was regulated by GDNF.
GDNF Spec (whether) Regulation (regulated) of CGRP in glial cell associated with calcitonin gene-related peptide
1) Confidence 0.53 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14656320 Disease Relevance 0.25 Pain Relevance 0.57
However, this normalization procedure led to a relative reduction in the GDNF effect on CAP-evoked CGRP release, such that only the 10 ng/ml condition reached a significant increase in CGRP outflow.
GDNF Regulation (effect) of CGRP release in outflow associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.11 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.46

General Comments

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