INT115045

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 3.88
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem) DNA binding (Crem)
Anatomy Link Frequency
brain 5
spinal cord 1
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 34 100.00 Very High Very High Very High
Spinal cord 4 98.40 Very High Very High Very High
antidepressant 44 97.72 Very High Very High Very High
addiction 79 96.32 Very High Very High Very High
Kappa opioid receptor 1 93.52 High High
analgesia 2 91.12 High High
Hippocampus 64 90.92 High High
Opioid 3 89.56 High High
Desipramine 22 85.44 High High
Visceral pain 1 84.84 Quite High
Disease Link Frequency Relevance Heat
Convulsion 110 99.98 Very High Very High Very High
Apoptosis 92 99.78 Very High Very High Very High
Drug Dependence 51 96.72 Very High Very High Very High
Death 22 96.12 Very High Very High Very High
Stress 121 94.92 High High
Epilepsy 66 93.84 High High
Injury 11 90.28 High High
Drug Induced Neurotoxicity 11 89.96 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 84.84 Quite High
Targeted Disruption 276 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular levels of ICER protein are controlled by transcription regulation and by protein degradation through the ubiquitin–proteasome system [30].
Regulation (controlled) of ICER protein
1) Confidence 0.61 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0.03
Further detailed examination of other types of memory is necessary in order to fully delineate memory systems critically dependent on CREB/ICER regulation.


Regulation (regulation) of ICER
2) Confidence 0.61 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.17 Pain Relevance 0.11
The apparent discrepancy of the above findings might be due to differences between the effects of constitutive changes in ICER levels (in the case of gene manipulations) and the effects of transient ICER upregulation (in the case of intact systems).
Regulation (changes) of ICER
3) Confidence 0.54 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.48 Pain Relevance 0.05
Another possible explanation is that the effects of whole forebrain (or brain) changes in ICER levels differ from those of region-specific changes in ICER levels.
Regulation (changes) of ICER in brain
4) Confidence 0.54 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.40 Pain Relevance 0.04
Accordingly, manipulations of ICER levels may, depending on the context, play both positive and negative roles in the organism.
Regulation (manipulations) of ICER
5) Confidence 0.45 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.11 Pain Relevance 0
Recent findings [62] suggest that in the intact brain the pro-apoptotic action of ICER may be more tightly regulated and less pronounced [21], thus explaining the discrepancy between the in vitro and in vivo findings.


Regulation (regulated) of ICER in brain associated with apoptosis
6) Confidence 0.45 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 1.05 Pain Relevance 0
Their model demonstrated that CREB overexpression in the brain had an inconsistent influence upon expression of other members of the CREB/ATF family (invariably downregulating though), paricularly CREM.
Regulation (influence) of CREM in brain
7) Confidence 0.36 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.14 Pain Relevance 0.14
Furthermore, in spinal cord nuclear protein extracts, the activity of the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), the main regulator of prodynorphin expression, is lower in IFD than in AL mice.
Regulation (regulator) of downstream regulatory element antagonist modulator in spinal cord associated with antagonist and spinal cord
8) Confidence 0.29 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14657170 Disease Relevance 0.24 Pain Relevance 0.95
But even with this constraint, the data obtained so far provide valuable insight into the role of ICER regulation of CRE-mediated transcription in brain function, firmly positioning it as an important “stimulus-transcription coupling” agent [109, 110].
Regulation (regulation) of ICER in brain
9) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.23 Pain Relevance 0
Intracellular levels of ICER protein are controlled by transcription regulation and by protein degradation through the ubiquitin–proteasome system [30].
Regulation (regulation) of ICER protein
10) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0.03
Seizures alter the activity of the CREB/CREM/ATF-1 gene family and their target genes.
Regulation (alter) of CREM associated with convulsion
11) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.59 Pain Relevance 0.28
Its low basal level of expression and high inducibility in response to various types of stimulation suggest that ICER is an ideal potential target for memory-improving manipulations.
Regulation (target) of ICER
12) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.06 Pain Relevance 0.03
Another possible explanation is that the effects of whole forebrain (or brain) changes in ICER levels differ from those of region-specific changes in ICER levels.
Regulation (changes) of ICER in brain
13) Confidence 0.27 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.35 Pain Relevance 0.04

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