INT115046

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 68
Total Number 68
Disease Relevance 27.24
Pain Relevance 10.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem) DNA binding (Crem)
Anatomy Link Frequency
neuronal 9
nucleus accumbens 4
forebrain 3
brain 2
hippocampus 2
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 183 100.00 Very High Very High Very High
Hippocampus 339 99.84 Very High Very High Very High
Glutamate receptor 60 99.84 Very High Very High Very High
Nucleus accumbens 387 99.80 Very High Very High Very High
orphanin 120 99.72 Very High Very High Very High
amygdala 139 99.68 Very High Very High Very High
depression 187 99.64 Very High Very High Very High
antidepressant 240 99.12 Very High Very High Very High
agonist 61 99.06 Very High Very High Very High
Eae 428 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1495 100.00 Very High Very High Very High
Repression 120 100.00 Very High Very High Very High
Stress 663 99.82 Very High Very High Very High
Anxiety Disorder 762 99.72 Very High Very High Very High
Depression 188 99.64 Very High Very High Very High
Death 132 99.28 Very High Very High Very High
Apoptosis 496 98.00 Very High Very High Very High
Injury 60 96.84 Very High Very High Very High
Drug Induced Neurotoxicity 60 96.52 Very High Very High Very High
Convulsion 600 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous ICER expression is also upregulated in a variety of cell cultures undergoing apoptosis [59–62].
Gene_expression (expression) of ICER associated with apoptosis
1) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.77 Pain Relevance 0
Interestingly, some cell culture studies showed that histone deacetylase (HDAC) is required for the induction of ICER expression [36, 37].
Gene_expression (expression) of ICER
2) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.37 Pain Relevance 0.34
The same authors have found that overexpression of ICER also affects an animal’s responses to natural rewards, leading to increased preference of familiar sucrose solution and increased social reward.
Gene_expression (overexpression) of ICER
3) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.14 Pain Relevance 0.38
Although rAAV-mediated ICER overexpression was widespread and robust, it did not cover 100% of hippocampal neurons.
Gene_expression (overexpression) of ICER in neurons
4) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.19 Pain Relevance 0.12
Stress induces ICER expression in different parts of the HPA axis, and ICER regulates transcription of the CRH gene during stress [24, 25, 45].
Gene_expression (expression) of ICER associated with stress
5) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.93 Pain Relevance 0.25
Studies using different types of stimulation have demonstrated that ICER induction is relatively slow compared to the induction time course of other immediate early genes (IEGs; ICER expression peaks around 2–6 h after stimulation, depending on types of stimulation and cell types).
Gene_expression (expression) of ICER
6) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.15 Pain Relevance 0.06
It might also be the case that ICER-induced inhibition of transcription play a crucial role in “single-trial” or “sub-threshold” learning, but more robust repeated training (as in an odor discrimination task) is able to overcome the effects of loss or overexpression of ICER.
Gene_expression (overexpression) of ICER
7) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.25 Pain Relevance 0.07
Overexpression of ICER, achieved through gene manipulation or viral vectors, is a powerful tool.
Gene_expression (Overexpression) of ICER
8) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.24 Pain Relevance 0
Exploration of enriched environments upregulates ICER expression in the barrel-related columns of primary somatosensory cortex, an important site related to familiarization with novel environments and learning about new stimuli [31, 32].
Gene_expression (expression) of ICER in primary somatosensory cortex associated with primary somatosensory cortex
9) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.08 Pain Relevance 0.13
As expression of ICER may be induced by the same stimuli and through the same molecular cascades that initiate formation of memory traces, ICER may play an overall positive role in the formation of adaptively meaningful learning and memory.
Gene_expression (expression) of ICER
10) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.38 Pain Relevance 0.18
In addition, overexpression of ICER in the nucleus accumbens strongly potentiates amphetamine-induced locomotor activity [46].
Gene_expression (overexpression) of ICER in nucleus accumbens associated with nucleus accumbens and eae
11) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.15 Pain Relevance 0.35
However, while considering these results, one needs to be aware that the consequences of stable and long-lasting overexpression of ICER may be different from the consequences of the phasic, transient changes in gene expression that takes place under normal conditions in response to different incoming stimuli [46].
Gene_expression (overexpression) of ICER
12) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.21 Pain Relevance 0
Overexpression of ICER in the nucleus accumbens increases responsiveness to natural rewards such as familiar sucrose and social interaction, and produces antidepressant-like effects in the forced swim test [46].
Gene_expression (Overexpression) of ICER in nucleus accumbens associated with nucleus accumbens, antidepressant and eae
13) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.89 Pain Relevance 0.28
Antidepressant and amphetamine treatments also upregulate ICER expression [46, 47], as do lithium chloride and nociceptin injections [48–50].
Gene_expression (expression) of ICER associated with antidepressant and orphanin
14) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.49 Pain Relevance 0.41
Neither overexpression nor deletion of ICER affected memory tested in the odor discrimination task [21].
Gene_expression (overexpression) of ICER
15) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.28 Pain Relevance 0.03
However, studies employing in vivo ICER overexpression did not report any signs of neuronal cell death [20, 21, 46].
Gene_expression (overexpression) of ICER in neuronal associated with death
16) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 1.00 Pain Relevance 0
Overexpression of ICER led to impaired long-term tone- and context-dependent fear memory, leaving short-term memory unchanged (Fig. 2a).
Gene_expression (Overexpression) of ICER associated with anxiety disorder
17) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 1.04 Pain Relevance 0.04
Purely physiological stimulation, such as exposure of dark-reared rats to light [39] and exploration of enriched environments [31, 32], also have the capacity to substantially upregulate ICER expression.
Gene_expression (expression) of ICER
18) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.46 Pain Relevance 0.34
Both agonists and antagonists of glutamate receptors induce ICER mRNA expression [39, 41–43].
Gene_expression (expression) of ICER mRNA associated with glutamate receptor, antagonist and agonist
19) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.52 Pain Relevance 0.44
Stimuli evoking neuronal cell death in the brain upregulate endogenous ICER expression [39].
Gene_expression (expression) of ICER in neuronal associated with death
20) Confidence 0.77 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.66 Pain Relevance 0

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