INT115048

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnip3, Pdyn) transport (Kcnip3) Golgi apparatus (Kcnip3)
endoplasmic reticulum (Kcnip3) intracellular (Kcnip3) DNA binding (Kcnip3)
Anatomy Link Frequency
spinal cord 2
Kcnip3 (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 53 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Spinal cord 4 98.54 Very High Very High Very High
Dynorphin 3 96.32 Very High Very High Very High
Kappa opioid receptor 1 93.80 High High
analgesia 2 91.40 High High
Opioid 2 89.84 High High
opiate 1 86.72 High High
Visceral pain 1 85.12 High High
Lasting pain 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 85.12 High High
Pain 5 84.24 Quite High
Nociception 5 84.24 Quite High
Depression 31 69.48 Quite High
Anxiety Disorder 24 50.00 Quite Low
Targeted Disruption 21 28.20 Quite Low
Shock 9 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Brain Disease 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in spinal cord nuclear protein extracts, the activity of the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), the main regulator of prodynorphin expression, is lower in IFD than in AL mice.
DREAM Regulation (regulator) of Gene_expression (expression) of prodynorphin in spinal cord associated with antagonist and spinal cord
1) Confidence 0.27 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14657170 Disease Relevance 0.24 Pain Relevance 0.96
Second, DREAM may affect NMDA receptor function through the control of prodynorphin gene expression [34,35].
DREAM Regulation (control) of Gene_expression (expression) of prodynorphin gene associated with nmda receptor
2) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.39 Pain Relevance 0.82

General Comments

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