INT115049

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn) nucleus (Crem) DNA binding (Crem)
Anatomy Link Frequency
spinal cord 2
Crem (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
Spinal cord 4 98.40 Very High Very High Very High
Kappa opioid receptor 1 93.52 High High
analgesia 2 91.12 High High
Opioid 2 89.56 High High
Dynorphin 1 86.00 High High
Visceral pain 1 84.84 Quite High
Pain 2 75.28 Quite High
MU agonist 1 73.92 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 84.84 Quite High
Nociception 2 84.24 Quite High
Pain 2 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in spinal cord nuclear protein extracts, the activity of the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), the main regulator of prodynorphin expression, is lower in IFD than in AL mice.
downstream regulatory element antagonist modulator Regulation (regulator) of Gene_expression (expression) of prodynorphin in spinal cord associated with antagonist and spinal cord
1) Confidence 0.20 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14657170 Disease Relevance 0.24 Pain Relevance 0.96

General Comments

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