INT11506

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 22.89
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
uterine 3
eye 1
tear 1
superior 1
epithelial cells 1
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 5 98.32 Very High Very High Very High
Inflammation 12 98.00 Very High Very High Very High
Dismenorea 3 97.04 Very High Very High Very High
backache 1 96.80 Very High Very High Very High
cytokine 2 93.40 High High
Pain 1 93.20 High High
iatrogenic 1 90.08 High High
pain pelvic 1 89.68 High High
anesthesia 29 72.00 Quite High
imagery 20 71.68 Quite High
Disease Link Frequency Relevance Heat
Syndrome 584 100.00 Very High Very High Very High
Reprotox - General 3 4 99.98 Very High Very High Very High
Ovarian Cysts 8 99.92 Very High Very High Very High
Dry Eye 293 99.52 Very High Very High Very High
Malignant Neoplastic Disease 29 99.52 Very High Very High Very High
Ovarian Cancer 285 99.44 Very High Very High Very High
Pancreatic Cancer 100 99.36 Very High Very High Very High
Disease 98 99.24 Very High Very High Very High
Endometriosis 6 99.16 Very High Very High Very High
Sjoegrens Syndrome 301 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Danjo et al. [30], using immunolocalization, noted that superficial temporal conjunctival epithelial cells did not bind the H185 antibody (MUC16) in non-SS dry eye as well as in normal subjects.
MUC16 Neg (not) Binding (bind) of in eye associated with syndrome and dry eye
1) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.04 Pain Relevance 0
All three groups had similar concentrations of membrane bound MUC16.
MUC16 Binding (bound) of
2) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.82 Pain Relevance 0
Our finding of excess MUC16 on the SS ocular surface, was particularly interesting to the clinical author (B.C.) who has long observed that excess ocular mucus is a common clinical finding in SS patients.
MUC16 Spec (finding) Binding (finding) of associated with syndrome
3) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.11 Pain Relevance 0
In conclusion, serum S-Tn antigen has limited use in diagnosing early stage ovarian cancer and uterine malignancies, but it can detect with accuracy ovarian cancers when used in a combination assay with CA 125 and can monitor the status of disease after therapy.
CA 125 Binding (assay) of in uterine associated with ovarian cancer and disease
4) Confidence 0.36 Published 1992 Journal Cancer Section Abstract Doc Link 1562985 Disease Relevance 1.20 Pain Relevance 0
Increased association of elevated levels of CA 125 and CA 15-3 is not so common in advanced endometriosis.
CA 125 Binding (association) of associated with endometriosis
5) Confidence 0.36 Published 2008 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 18754302 Disease Relevance 0.64 Pain Relevance 0.22
Pedunculated uterine leiomyoma associated with pseudo-Meigs' syndrome and elevated CA-125 level: CT features.
CA-125 Binding (associated) of in uterine associated with reprotox - general 3 and syndrome
6) Confidence 0.36 Published 2002 Journal Eur Radiol Section Title Doc Link 12522621 Disease Relevance 0.77 Pain Relevance 0.10
In conjunction with CA 125 and CASA the predictive value of TN for residual tumor was greatly improved, as the markers were found to supplement each other.
CA 125 Binding (conjunction) of associated with residual neoplasm
7) Confidence 0.36 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.75 Pain Relevance 0
Membrane bound MUC16 was similar in all three groups.
MUC16 Binding (bound) of
8) Confidence 0.36 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2613075 Disease Relevance 1.30 Pain Relevance 0.07
Data reported by Spurr-Michaud et al. [23] describing the presence of MUC16 in the tear film is confirmed by our results.
MUC16 Binding (presence) of in tear
9) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.95 Pain Relevance 0
Lastly, no difference between membrane bound MUC16 was found between any groups (p>0.05; Figure 4).
MUC16 Binding (bound) of
10) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.94 Pain Relevance 0
There were no differences found in membrane bound MUC16 protein concentration between any of the groups and no difference in any form of MUC16 found between the KCS and NDE groups.
MUC16 protein Binding (bound) of associated with sjoegrens syndrome and eye disease
11) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.12 Pain Relevance 0
An association between reduced membrane bound mucins, specifically MUC16, and the presence of rose bengal staining has been suggested by Danjo et al. [33] in human cells, and Argueso et al. [25] in human corneal-limbal epithelial cells lines (HCLE).
MUC16 Binding (bound) of in epithelial cells
12) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.83 Pain Relevance 0
This two-marker combination yielded sensitivities at 98% specificity of 72% for all cases and 86% for serous cases only, compared to sensitivities at 98% specificity for MUC16 alone of 70% (all cases) and 86% (serous cases).
MUC16 Binding (specificity) of
13) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.28 Pain Relevance 0
Thus, given the potential relevance of our findings, further investigation of these MUC16 in larger groups is warranted.
MUC16 Binding (investigation) of
14) Confidence 0.32 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.91 Pain Relevance 0
Recent work by Argueso et al. [49], however, suggests that, in vitro, it is the interaction of the carbohydrate binding protein galectin-3 with the carbohydrate portion of both MUC1 and MUC16 that creates a protective barrier to the penetration of dye such as rose bengal.
MUC16 Binding (interaction) of
15) Confidence 0.31 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.73 Pain Relevance 0
For example, consider a patient with normalized MUC16?
MUC16 Binding (patient) of
16) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0 Pain Relevance 0
If all transmembrane mucins are involved in resisting rose bengal penetration, then these data conflict in principle with our findings of increased levels of membrane bound MUC1 in SS versus NDE and no difference in membrane bound MUC16 in our previous work with SS, KCS and NDE [30], since rose bengal staining is found clinically in greater amounts in Sjogren’s syndrome patients [48].
MUC16 Binding (bound) of associated with sjoegrens syndrome, syndrome and dry eye
17) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.79 Pain Relevance 0
The management of an adnexal masses involves several steps: establish the diagnosis of organic ovarian cyst, avoiding a useless and iatrogenic surgery of a functional cyst, knowing that functional cysts may persist more than 3 months and may occur even on low-dose oral contraceptives; cure painful cysts, by ultrasound guided aspiration of some functional cysts or laparoscopic detorsion of twisted adnexae; exclude malignancy, with the help of ultrasound, Doppler and Ca-125 preoperatively, then laparoscopic examination and pathology; failed diagnosis of cancer becomes rare (1 out of 300 laparoscopic surgeries for ovarian cyst); the association of a benign ultrasound and Doppler pattern and of a Ca-125 lower than 35 mUI/ml is almost pathognomonic of a benign cyst; cure benign ovarian cysts with a minimum of surgical trauma; in our series, 84.4% of ovarian cysts are managed laparoscopically, 11.1% by elective laparotomy, 4.5% by laparotomy after an attempt at laparoscopic surgery (that implies that the patient must be informed of the risk of laparotomy); adapt the surgical technique to the pathologic type and size of the cyst, with a high rate of laparotomy in large dermoid cysts, and a high rate of (salpingo-)oophorectomy in peri or postmenopausal cysts; ensure an adequate therapy of early ovarian carcinomas, avoiding understadification and undertreatment; prevent ovarian cancer by a careful long-term follow-up of patients with benign ovarian cysts and by the use of bilateral oophorectomy in postmenopausal patients.
Ca-125 Binding (association) of associated with pain, ovarian cancer, cyst, iatrogenic, malignant neoplastic disease, dermoids, cancer, injury and ovarian cysts
18) Confidence 0.29 Published 1993 Journal Contracept Fertil Sex Section Abstract Doc Link 7951609 Disease Relevance 1.67 Pain Relevance 0.14
To date, no studies have implicated CA125 for utility in pancreatic cancer prognosis.
CA125 Binding (implicated) of associated with pancreatic cancer
19) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 0.99 Pain Relevance 0.04
In this study, we found that a combination of CEA and CA125 has superior prognostic value for locally advanced pancreatic cancer in two survival models.
CA125 Binding (combination) of in superior associated with pancreatic cancer
20) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2796647 Disease Relevance 0.70 Pain Relevance 0.05

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