INT115069

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.31
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CeA 2
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 56 100.00 Very High Very High Very High
gABA 24 100.00 Very High Very High Very High
alcohol 11 94.12 High High
withdrawal 2 86.92 High High
opiate 1 86.00 High High
Pain 2 74.80 Quite High
GABAergic 16 50.00 Quite Low
addiction 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 55 100.00 Very High Very High Very High
Anxiety Disorder 12 95.80 Very High Very High Very High
Recurrence 2 92.28 High High
Stress 2 91.28 High High
Death 36 89.84 High High
Stroke 70 89.44 High High
Alcohol Addiction 8 86.92 High High
Pseudomyxoma Peritonei 44 84.20 Quite High
Ovarian Cancer 2 79.32 Quite High
Embolism 4 72.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
serves two roles in the CeA: (i) to reduce spontaneous baseline GABA release, and (ii) to mediate CRF- and ethanol-stimulated release of GABA.
Positive_regulation (stimulated) of Localization (release) of CeA associated with gaba and amygdala
1) Confidence 0.34 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.46 Pain Relevance 0.58
There now exists the highest level of evidence (AHA/ACC class I, level of evidence A) that there is clinical equipoise between CAS and CEA for patients at increased surgical risk for CEA.
Positive_regulation (increased) of Localization (equipoise) of CEA
2) Confidence 0.33 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948384 Disease Relevance 0.73 Pain Relevance 0
There now exists the highest level of evidence (AHA/ACC class I, level of evidence A) that there is clinical equipoise between CAS and CEA for patients at increased surgical risk for CEA.
Positive_regulation (increased) of Localization (equipoise) of CEA
3) Confidence 0.33 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948384 Disease Relevance 0.73 Pain Relevance 0
The position is offered that although release of CRH within the CeA is increased under stressful conditions, it is not a necessary condition for the consequent behavioral expression of anxiety-like reactions, at least not in minimally threatening situations.
Positive_regulation (increased) of Localization (release) of CeA in CeA associated with anxiety disorder and amygdala
4) Confidence 0.32 Published 2003 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 14659475 Disease Relevance 0.63 Pain Relevance 0.37
Similar to our findings, mucinous deposits were reported to be positive for alcian blue staining, and serum levels of CEA were elevated in tumor bearing mice compared to control mice, indicating relevance of CEA in this model as well.
Positive_regulation (elevated) of Localization (relevance) of CEA associated with cancer
5) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 0.77 Pain Relevance 0

General Comments

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