INT115070

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 3.80
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
spinal nerve 1
dorsal root ganglia 1
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 99.78 Very High Very High Very High
addiction 8 99.16 Very High Very High Very High
Pain 104 99.12 Very High Very High Very High
Hyperalgesia 11 97.64 Very High Very High Very High
central sensitization 2 96.92 Very High Very High Very High
ASIC 126 95.84 Very High Very High Very High
Inflammation 136 94.08 High High
wide dynamic range 3 90.16 High High
ischemia 33 88.16 High High
Potency 8 81.40 Quite High
Disease Link Frequency Relevance Heat
Pain 97 99.12 Very High Very High Very High
Aids-related Complex 64 98.96 Very High Very High Very High
Hyperalgesia 11 97.64 Very High Very High Very High
Acidosis 112 96.08 Very High Very High Very High
Cancer 16 96.00 Very High Very High Very High
Injury 25 95.52 Very High Very High Very High
Infection 24 95.20 Very High Very High Very High
INFLAMMATION 152 94.08 High High
Cv Unclassified Under Development 16 83.04 Quite High
Inflammatory Pain 56 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, AGM evokes ASIC3-dependent pain-behavior in mice [10], suggesting that AGM-ASIC3 interaction may become functionally relevant under pathological conditions.


ASIC3 Binding (interaction) of associated with pain
1) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.86 Pain Relevance 0.40
The extracellular Ca2+ concentration can decrease from a resting value of around 1.2-1.8 mM to values as low as 0.08 mM under certain conditions [38], suggesting that the signaling cascade induced by AGM-ASIC3 interaction might be markedly amplified under such conditions.
ASIC3 Binding (interaction) of
2) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.11
To understand the functional relevance of AGM-ASIC3 interaction, we examined the pH dependence of AGM action by applying graded pH to the CHO cell expressing ASIC3 channels, in the presence or absence of AGM (Figure 2A).
ASIC3 Binding (interaction) of associated with addiction
3) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.83 Pain Relevance 0.31
Therefore, interfering with ASIC3 might be of benefit in treatment or prevention of chronic hyperalgesia.
ASIC3 Binding (interfering) of associated with hyperalgesia
4) Confidence 0.37 Published 2003 Journal Pain Section Abstract Doc Link 14659506 Disease Relevance 0.52 Pain Relevance 0.79
After spinal nerve ligation, ASIC2 and ASIC3 knockout mice developed mechanical and heat hyperalgesia comparable with that of their respective WT controls.
ASIC3 Binding (ligation) of in spinal nerve
5) Confidence 0.37 Published 2010 Journal Anesthesiology Section Body Doc Link 20693874 Disease Relevance 0 Pain Relevance 0
However, heteromeric ASIC3 plus ASIC1b channels responded to AGM and ARC (Figure 7B, D) in a manner similar to homomeric ASIC3 channels (Figure 7A, C).
ASIC3 Binding (heteromeric) of associated with aids-related complex
6) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.29 Pain Relevance 0.20
On the other hand, heteromeric combinations of ASIC3 plus ASIC1a, ASIC2a, or ASIC2b were insensitive to these ligands (Figure 7B, D).
ASIC3 Binding (combinations) of
7) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.20
ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.
ASIC3 Binding (heteromultimerize) of in dorsal root ganglia associated with qutenza
8) Confidence 0.36 Published 2009 Journal Circ. Res. Section Title Doc Link 19590043 Disease Relevance 0 Pain Relevance 0.19
Interestingly, 2-(trimethylammonium)ethyl methanethiosulfonate (MTSET, 0.5 mM), a MTS reagent in which the amino group is replaced by a trimethylamine, failed to induce any detectable currents in ASIC3E79C-expressing CHO cells (Figure 6C), suggesting that the amino group in AGM plays an essential role in activating ASIC3 channels, as has been shown in GMQ-ASIC3 interaction [10].
ASIC3 Binding (interaction) of
9) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.06 Pain Relevance 0.14
Thus, similar to GMQ [10], AGM-ASIC3 interaction is highly sensitive to altered extracellular Ca2+.
ASIC3 Binding (interaction) of
10) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.20 Pain Relevance 0.10
AGM-induced ASIC3 channel activation was not through the chelation of extracellular Ca2+ as occurs with increased lactate, but rather through a direct interaction with the newly identified nonproton ligand sensing domain.
ASIC3 Binding (interaction) of
11) Confidence 0.35 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3017031 Disease Relevance 0.50 Pain Relevance 0.27

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