INT115074

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.66
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
neuronal 1
skin 1
dorsal horn 1
hippocampus 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 20 99.84 Very High Very High Very High
Glutamate receptor 38 99.72 Very High Very High Very High
Dorsal horn neuron 5 98.72 Very High Very High Very High
long-term potentiation 46 98.24 Very High Very High Very High
addiction 4 97.72 Very High Very High Very High
Hippocampus 45 97.40 Very High Very High Very High
Anterior cingulate cortex 5 96.72 Very High Very High Very High
IPN 2 96.72 Very High Very High Very High
hyperexcitability 10 95.72 Very High Very High Very High
Nucleus accumbens 11 93.84 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 13 99.90 Very High Very High Very High
Disease 20 97.00 Very High Very High Very High
Inflammatory Pain 2 96.72 Very High Very High Very High
Schizophrenia 4 95.64 Very High Very High Very High
Anxiety Disorder 29 93.40 High High
INFLAMMATION 7 90.80 High High
Pain 3 85.28 High High
Autism 10 79.12 Quite High
Intellectual Impairment 12 78.68 Quite High
Neurological Disease 16 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, they suggest a dependence-associated shift in the molecular mechanisms that regulate the consequences of D1 receptor stimulation, favoring activation of GluR1 rather than CREB.
Positive_regulation (activation) of GluR1 associated with addiction
1) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.07 Pain Relevance 1.40
Treatment of cultured dorsal horn neurons with IFN-gamma for 2 weeks resulted in a significantly reduced clustering of alpha-amino-3-hydroxy-5-methylisoxazole (AMPA) receptor subunit 1 (GluR1) that was dependent on nitric oxide.
Positive_regulation (clustering) of GluR1 in dorsal horn associated with dorsal horn neuron
2) Confidence 0.49 Published 2003 Journal Pain Section Abstract Doc Link 14659507 Disease Relevance 0.26 Pain Relevance 0.71
A recent study has shown that norepinephrine-driven phosphorylation of GluR1 subunit may facilitate AMPA receptor trafficking to synaptic sites and LTP induction in the hippocampus [75].
Spec (may) Positive_regulation (facilitate) of AMPA in hippocampus associated with hippocampus and long-term potentiation
3) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.22 Pain Relevance 0.52
Here we use whole-cell patch clamp recordings to demonstrate that cingulate LTP requires the functional recruitment of GluR1 AMPA receptors; and such events are rapid and completed within 5-10 min after LTP induction.
Positive_regulation (requires) of GluR1
4) Confidence 0.49 Published 2007 Journal Dev Neurobiol Section Abstract Doc Link 17443804 Disease Relevance 0.26 Pain Relevance 0.39
For example, increased AMPA-to-NMDA receptor ratios were found in patients afflicted with Alzheimer's disease (Snyder et al., 2005) and schizophrenia (Mohn et al., 1999).
Positive_regulation (increased) of AMPA associated with nmda receptor, disease and schizophrenia
5) Confidence 0.05 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.76 Pain Relevance 0.34
Likewise, increased postsynaptic AMPA-to-NMDA receptor ratios ensure basal synaptic transmission at the expense of synaptic plasticity.
Positive_regulation (increased) of AMPA associated with nmda receptor
6) Confidence 0.05 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0.82 Pain Relevance 0.34
Interestingly, using our neuronal induction protocol, we also observed that genes implicated in neurogenesis are increased and specially those in relation with the synaptic transmission (AMPA, synaptotagmin, CASK, Syntaxin 1A, SNCAIP, MCT2).
Positive_regulation (increased) of AMPA in neuronal associated with neurodegenerative disease
7) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.10 Pain Relevance 0
BACKGROUND: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazolone-4-propionic acid (AMPA), and kainate (KA) receptors are members of the ionotropic glutamate receptor (iGluR) family and are increased in inflamed rat skin.
Positive_regulation (increased) of iGluR in skin associated with glutamate receptor
8) Confidence 0.01 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18238837 Disease Relevance 0.17 Pain Relevance 0.31
Much evidence supports the view that DOM and KA are excitotoxic and their toxic effect is mediated through the activation of iGluRs with the participation and co-activation of AMPA/KA and NMDA receptor subtypes [46,48,61,63,67,79,80,181,193–197].
Positive_regulation (activation) of AMPA associated with nmda receptor
9) Confidence 0.01 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0 Pain Relevance 0.28
AMPA activation causes cellular depolarisation and NMDA channel opening with Ca2+ influx.
Positive_regulation (activation) of AMPA
10) Confidence 0.00 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0 Pain Relevance 0.18

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