INT115075

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2003
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
neurons 4
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 8 97.88 Very High Very High Very High
Dorsal horn 4 96.12 Very High Very High Very High
agonist 2 82.44 Quite High
central sensitization 6 81.52 Quite High
Dorsal horn neuron 10 75.00 Quite High
antagonist 2 73.32 Quite High
hyperexcitability 4 50.64 Quite High
Inflammation 4 45.72 Quite Low
cytokine 2 40.76 Quite Low
Pain 2 35.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 45.72 Quite Low
Pain 2 35.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since GluR1-containing AMPA receptors (AMPARs) occur predominantly on inhibitory neurons in the dorsal horn, we suggest that the IFN-gamma-mediated increase in spontaneous activity and responsiveness to DRG axon stimulation, decrease in sensitivity to PTX and tendency for EPSC bursting result from a reduced expression of GluR1 on these neurons and not from a reduction in active GABA(A) receptors in the network.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of GluR1 in neurons associated with gaba and dorsal horn
1) Confidence 0.57 Published 2003 Journal Pain Section Abstract Doc Link 14659507 Disease Relevance 0 Pain Relevance 0.54
Since GluR1-containing AMPA receptors (AMPARs) occur predominantly on inhibitory neurons in the dorsal horn, we suggest that the IFN-gamma-mediated increase in spontaneous activity and responsiveness to DRG axon stimulation, decrease in sensitivity to PTX and tendency for EPSC bursting result from a reduced expression of GluR1 on these neurons and not from a reduction in active GABA(A) receptors in the network.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of GluR1 in neurons associated with gaba and dorsal horn
2) Confidence 0.41 Published 2003 Journal Pain Section Abstract Doc Link 14659507 Disease Relevance 0 Pain Relevance 0.54

General Comments

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