INT115076

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
dorsal horn 2
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 5 98.88 Very High Very High Very High
hyperexcitability 2 96.04 Very High Very High Very High
Inflammation 2 91.12 High High
cytokine 1 86.16 High High
Pain 1 80.56 Quite High
central sensitization 3 79.56 Quite High
gABA 4 72.24 Quite High
antagonist 1 70.88 Quite High
agonist 1 52.48 Quite High
Dorsal horn 2 33.12 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 91.12 High High
Pain 1 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of cultured dorsal horn neurons with IFN-gamma for 2 weeks resulted in a significantly reduced clustering of alpha-amino-3-hydroxy-5-methylisoxazole (AMPA) receptor subunit 1 (GluR1) that was dependent on nitric oxide.
Negative_regulation (reduced) of Positive_regulation (clustering) of GluR1 in dorsal horn associated with dorsal horn neuron
1) Confidence 0.41 Published 2003 Journal Pain Section Abstract Doc Link 14659507 Disease Relevance 0.26 Pain Relevance 0.72

General Comments

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