INT11508

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 19.81
Pain Relevance 15.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TGFBI) extracellular space (TGFBI) extracellular region (TGFBI)
plasma membrane (TGFBI) extracellular matrix organization (TGFBI)
Anatomy Link Frequency
nociceptors 2
neocortex 2
cortex 2
SK-MEL-28 1
cerebrospinal fluid 1
TGFBI (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 176 100.00 Very High Very High Very High
amygdala 28 99.92 Very High Very High Very High
Spinal cord 8 99.92 Very High Very High Very High
headache 6 99.92 Very High Very High Very High
bradykinin 1 99.64 Very High Very High Very High
Migraine 31 99.56 Very High Very High Very High
Calcitonin gene-related peptide 7 99.52 Very High Very High Very High
Hippocampus 16 99.48 Very High Very High Very High
adenocard 5 99.34 Very High Very High Very High
halothane 9 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 176 100.00 Very High Very High Very High
Neurodegenerative Disease 3 100.00 Very High Very High Very High
Glaucoma 94 99.92 Very High Very High Very High
Migraine Disorders 3 99.92 Very High Very High Very High
Injury 6 99.08 Very High Very High Very High
Metastasis 26 97.80 Very High Very High Very High
Anaerobic Bacterial Infections 4 96.76 Very High Very High Very High
Breast Cancer 4 96.68 Very High Very High Very High
Pain 7 96.44 Very High Very High Very High
Frailty 4 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the probability of two mutations occurring in both TGFBI and KRT3 (or KRT12) in two unrelated Chinese families should be extremely rare.
Positive_regulation (occurring) of TGFBI
1) Confidence 0.70 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443752 Disease Relevance 0 Pain Relevance 0
The findings demonstrates for the first time that induction of CSD by focal stimulation of the rat visual cortex can lead to long-lasting activation of nociceptors that innervate the meninges.
Positive_regulation (induction) of CSD in nociceptors associated with depression and nociceptor
2) Confidence 0.67 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592202 Disease Relevance 1.09 Pain Relevance 1.21
CSD was induced via cortical pinprick injury or KCl injection in the somatosensory cortex.
Positive_regulation (induced) of CSD in cortex associated with somatosensory cortex, depression and injury
3) Confidence 0.58 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 14751772 Disease Relevance 1.22 Pain Relevance 1.03
Regardless of the method of cortical stimulation, induction of CSD was recorded in 64 trials.
Positive_regulation (induction) of CSD associated with depression
4) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592202 Disease Relevance 1.23 Pain Relevance 1.18
CSD was induced in anesthetized male rats by stimulation of the visual cortex with electrical pulses, pin prick, or KCl; single-unit activity of meningeal nociceptors was monitored in vivo in the rat before and after CSD.
Positive_regulation (induced) of CSD in nociceptors associated with depression and nociceptor
5) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592202 Disease Relevance 1.14 Pain Relevance 1.09
induced TGFBI gene were amplified by polymerase chain reaction and directly sequenced to verify the mutation.
Positive_regulation (induced) of TGFBI
6) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2443752 Disease Relevance 0 Pain Relevance 0
induced (TGFBI) gene are the main causes of LCD I [1].
Positive_regulation (induced) of TGFBI
7) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443752 Disease Relevance 0.26 Pain Relevance 0.09
Cortical impedance increased by 39% of the resting level during CSD.
Positive_regulation (increased) of CSD associated with depression
8) Confidence 0.40 Published 1992 Journal Clin Phys Physiol Meas Section Abstract Doc Link 1563223 Disease Relevance 0.62 Pain Relevance 0.41
Vascular reactivity was tested by local perivascular microapplication of mock cerebrospinal fluid (CSF) containing high and low levels of K+, high and low pH, adenosine and bradykinin before and after CSD which was triggered by intracortical injection of KCl.
Positive_regulation (triggered) of CSD in cerebrospinal fluid associated with adenocard, depression and bradykinin
9) Confidence 0.39 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607427 Disease Relevance 1.15 Pain Relevance 0.59
A corneal graft may be necessary in LCD1 by 20 years of age, but is usually not indicated until after the fourth decade.
Positive_regulation (necessary) of LCD1
10) Confidence 0.38 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.26 Pain Relevance 0
More than 75% of CSD induced in temporal cortex propagated to LA.
Positive_regulation (induced) of CSD in temporal cortex associated with depression and amygdala
11) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18412626 Disease Relevance 1.28 Pain Relevance 1.53
Induction of CSD in combined amygdala-hippocampus-cortex slices in which CSD propagated from neocortex to LA significantly augmented LTP in LA.
Positive_regulation (Induction) of CSD in neocortex associated with depression, long-term potentiation, hippocampus and amygdala
12) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18412626 Disease Relevance 1.29 Pain Relevance 1.59
Furthermore, CSD was induced in anaesthetized rats and, thereafter, hippocampal tissues were examined in vitro.
Positive_regulation (induced) of CSD associated with depression
13) Confidence 0.30 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553774 Disease Relevance 1.18 Pain Relevance 1.14
Induction of CSD in combined hippocampus-cortex slices in which DC negative deflections did not propagate from neocortex to hippocampus significantly augmented fEPSP amplitude and LTP in the hippocampus.
Positive_regulation (Induction) of CSD in hippocampus associated with depression, long-term potentiation and hippocampus
14) Confidence 0.30 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553774 Disease Relevance 1.03 Pain Relevance 0.99
After a basal recording of CSD induction during the first 40-min period, metoprolol (5 mg/kg) was infused within 4 min.
Positive_regulation (induction) of CSD associated with depression
15) Confidence 0.27 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17681024 Disease Relevance 0.75 Pain Relevance 0.45
CSD was induced with application of 1 m KCL through a burr hole into the left frontal dura-mater, and recorded by an Ag/AgCl DC electrode on the left parietal dura-mater.
Positive_regulation (induced) of CSD in parietal associated with depression
16) Confidence 0.27 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17681024 Disease Relevance 0.79 Pain Relevance 0.47
In contrast, CSD induced during inhalation of 0.5% or 2.0% halothane did not confer ischemic tolerance.
Positive_regulation (induced) of CSD associated with depression, tolerance and halothane
17) Confidence 0.27 Published 2005 Journal Brain Res. Section Abstract Doc Link 16256083 Disease Relevance 0.71 Pain Relevance 1.16
TGFBI was upregulated significantly by microarray (Table 3, Table 4), but not by qRT-PCR (Fig 5F).
Neg (not) Positive_regulation (upregulated) of TGFBI
18) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.54 Pain Relevance 0
Transcripts of the extracellular matrix protein TGFBI were elevated in our more invasive cell lines.
Positive_regulation (elevated) of TGFBI in extracellular matrix
19) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.53 Pain Relevance 0.11
CSD was triggered by a remote intracortical injection of KCl (150 mM) and recorded by a microelectrode placed adjacent to the artery under investigation.
Positive_regulation (triggered) of CSD in artery associated with depression
20) Confidence 0.11 Published 1994 Journal Brain Res. Section Abstract Doc Link 8180797 Disease Relevance 0.69 Pain Relevance 0.64

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