INT115084

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM1) nucleus (GRM1) signal transducer activity (GRM1)
Anatomy Link Frequency
spinal 2
GRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
c fibre 5 99.98 Very High Very High Very High
spinal dorsal horn 2 98.64 Very High Very High Very High
long-term potentiation 8 97.42 Very High Very High Very High
antagonist 5 84.88 Quite High
Glutamate receptor 2 75.00 Quite High
Sciatic nerve 1 48.40 Quite Low
Hyperalgesia 1 43.80 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 1 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the induction of LTP of C fibre-evoked field potentials in the spinal dorsal horn by high-frequency, high-intensity stimulation of afferent C fibres requires a group-specific mGluR recruitment, activation of mGluR1/5 but not that of mGluR4/6-8 and mGluR2/3 being a requisite step.
Positive_regulation (requires) of Positive_regulation (activation) of mGluR1 in spinal associated with c fibre, spinal dorsal horn and long-term potentiation
1) Confidence 0.49 Published 2003 Journal Pain Section Abstract Doc Link 14659520 Disease Relevance 0 Pain Relevance 0.88

General Comments

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