INT11509

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 66
Total Number 73
Disease Relevance 2.34
Pain Relevance 19.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc4a4)
Anatomy Link Frequency
duodenum 15
stomach 6
proximal 5
afferent neurons 4
sensory neurons 2
Slc4a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 33 99.90 Very High Very High Very High
qutenza 133 99.84 Very High Very High Very High
narcan 15 99.44 Very High Very High Very High
antagonist 78 99.36 Very High Very High Very High
Bile 11 99.20 Very High Very High Very High
agonist 23 99.16 Very High Very High Very High
noradrenaline 20 98.56 Very High Very High Very High
opiate 14 98.42 Very High Very High Very High
Endogenous opioid 10 97.90 Very High Very High Very High
Enkephalin 24 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 30 98.94 Very High Very High Very High
Cv Unclassified Under Development 9 97.40 Very High Very High Very High
Rheumatoid Arthritis 3 96.08 Very High Very High Very High
Diarrhoea 3 89.96 High High
Natriuresis 2 79.56 Quite High
Hypersensitivity 3 75.00 Quite High
Ulcers 1 67.36 Quite High
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mucosal exposure with sparkling water increased the secretion of HCO3- in both the stomach and duodenum.
Localization (secretion) of HCO3 in duodenum
1) Confidence 0.67 Published 2009 Journal Med. Sci. Monit. Section Body Doc Link 19946223 Disease Relevance 0 Pain Relevance 0
BACKGROUND: We examined the effect of sparkling water on gastroduodenal HCO3- secretion in rats and investigated the factors involved in these responses.
Localization (secretion) of HCO3
2) Confidence 0.67 Published 2009 Journal Med. Sci. Monit. Section Abstract Doc Link 19946223 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Sparkling water stimulates HCO3- secretion in both the stomach and the duodenum, but the mechanisms involved differ in these two tissues; the response in the former is mainly due to the intracellular supply of HCO3- with the aid of carbonic anhydrase, while in the latter the response is dependent on the NHE1, AE and NBC, and is mediated by endogenous prostaglandins as well as capsaicin-sensitive afferent neurons, in addition to the intracellular supply of HCO3-.


Localization (secretion) of HCO3 in duodenum
3) Confidence 0.67 Published 2009 Journal Med. Sci. Monit. Section Body Doc Link 19946223 Disease Relevance 0 Pain Relevance 0
We investigated the role of capsaicin-sensitive sensory neurons in regulation of gastroduodenal HCO3- secretion in anesthetized rats.
Localization (secretion) of HCO3 in sensory neurons associated with qutenza
4) Confidence 0.61 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8283013 Disease Relevance 0 Pain Relevance 0.29
We conclude that capsaicin-sensitive sensory neurons may be involved in the regulatory mechanism of gastroduodenal HCO3- secretion and contribute to protection of the mucosa against acid.
Localization (secretion) of HCO3 in sensory neurons associated with qutenza
5) Confidence 0.61 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8283013 Disease Relevance 0 Pain Relevance 0.52
These findings suggest that peripheral muscarinic M1 and nicotinic receptors mediate cholinergic stimulation of duodenal mucosal HCO3- secretion.
Localization (secretion) of HCO3
6) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048521 Disease Relevance 0 Pain Relevance 0.22
These results suggest that capsaicin-sensitive sensory nerves may be involved in the mechanism of acid-induced HCO3- secretion in the stomach, in addition to endogenous PGs, and these two pathways may interact somewhere in the stimulatory process.
Localization (secretion) of HCO3 in sensory nerves associated with qutenza
7) Confidence 0.61 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1563317 Disease Relevance 0 Pain Relevance 0.52
McN-A-343 (0.025, 0.25, and 2.5 mg/kg), an M1-selective agonist and ganglionic stimulator, increased the HCO3- secretion; this effect was not prevented by vagotomy but was attenuated by pirenzepine.
Localization (secretion) of HCO3 associated with agonist
8) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048521 Disease Relevance 0 Pain Relevance 0.26
The muscarinic M1-selective antagonists pirenzepine and telenzepine (0.025, 0.25 and 2.5 mg/kg) did not decrease but caused a dose-dependent rise in duodenal mucosal HCO3- secretion, an effect abolished by cervical vagotomy or infusion of the alpha-adrenoceptor antagonist phentolamine (0.1 mg.kg-1.h-1).
Localization (secretion) of HCO3 associated with antagonist
9) Confidence 0.61 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048521 Disease Relevance 0 Pain Relevance 0.26
Stimulation of alpha 2-adrenergic receptors on enterocytes normally promotes NaCl absorption and inhibits HCO3 secretion.
Localization (secretion) of HCO3 in enterocytes
10) Confidence 0.61 Published 1986 Journal Gastroenterology Section Abstract Doc Link 2874098 Disease Relevance 0.69 Pain Relevance 0.20
The role of capsaicin-sensitive afferent neurons in acid-induced HCO3- secretion was investigated in the duodenum of anesthetized rats.
Localization (secretion) of HCO3 in duodenum associated with qutenza
11) Confidence 0.61 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1889720 Disease Relevance 0 Pain Relevance 0.17
It was concluded that stimulation of capsaicin-sensitive afferent neurons increased duodenal HCO3- secretion and that these neurons may be involved in the mechanism of HCO3- response induced by luminal acid in the duodenum.
Localization (secretion) of HCO3 in duodenum associated with qutenza
12) Confidence 0.61 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1889720 Disease Relevance 0 Pain Relevance 0.61
These data demonstrate that H+ and HCO3- secretion in the fasting rat gastric lumen follow circadian rhythms with different peak times.
Localization (secretion) of HCO3 in lumen
13) Confidence 0.61 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 2018135 Disease Relevance 0.07 Pain Relevance 0.08
Stimulation by sparkling water of gastroduodenal HCO3- secretion in rats.
Localization (secretion) of HCO3 associated with qutenza
14) Confidence 0.59 Published 2009 Journal Med. Sci. Monit. Section Title Doc Link 19946223 Disease Relevance 0 Pain Relevance 0.10
MATERIAL/METHODS: Under urethane anesthesia, a chambered stomach or a proximal duodenal loop was superfused with saline, and HCO3- secretion was measured at pH 7.0 using a pH-stat.
Localization (secretion) of HCO3 in proximal
15) Confidence 0.59 Published 2009 Journal Med. Sci. Monit. Section Body Doc Link 19946223 Disease Relevance 0 Pain Relevance 0
Intravenous administration of L-NAME (1-5 mg/kg) increased HCO3- secretion in a dose-dependent manner in both the stomach and duodenum, with a concomitant elevation of arterial blood pressure.
Localization (secretion) of HCO3 in stomach
16) Confidence 0.55 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690403 Disease Relevance 0 Pain Relevance 0
HCO3- secretion was measured at pH 7.0 using a pH-stat method in the chambered stomach in the presence of omeprazole or in the proximal duodenum.
Localization (secretion) of HCO3 in duodenum
17) Confidence 0.55 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690403 Disease Relevance 0 Pain Relevance 0
Furthermore, the increased HCO3- secretion caused by L-NAME was significantly attenuated by prior administration of atropine (1 mg/kg, s.c.) or indomethacin (5 mg/kg, s.c.) and by bilateral vagotomy but was not influenced by sensory deafferentation after capsaicin pretreatment, though none of the treatments had any effect on the changes in blood pressure induced by L-NAME.
Localization (secretion) of HCO3 in blood associated with qutenza, cv unclassified under development and deafferentation
18) Confidence 0.55 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690403 Disease Relevance 0.09 Pain Relevance 0.14
These results suggest that L-NAME stimulates HCO3- secretion in the gastroduodenal mucosa.
Localization (secretion) of HCO3
19) Confidence 0.55 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690403 Disease Relevance 0.10 Pain Relevance 0.14
The role of nitric oxide (NO) in the regulation of gastroduodenal HCO3- secretion was investigated in anesthetized rats using the NO biosynthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME).
Spec (investigated) Localization (secretion) of HCO3
20) Confidence 0.55 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7690403 Disease Relevance 0 Pain Relevance 0

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