INT1151

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Context Info
Confidence 0.49
First Reported 1975
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.73
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK, GAST) extracellular region (CCK, GAST) extracellular space (CCK)
Anatomy Link Frequency
muscle 2
CCK (Homo sapiens)
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 153 100.00 Very High Very High Very High
agonist 4 71.44 Quite High
peptic ulcer disease 4 64.16 Quite High
tetrodotoxin 2 53.84 Quite High
antagonist 9 51.36 Quite High
Morphine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 3 89.76 High High
Ulcers 8 82.24 Quite High
Critical Illness 38 76.48 Quite High
Appetite Loss 2 65.80 Quite High
Eating Disorder 2 65.12 Quite High
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Sepsis 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to gastrin, CCK also recognizes CCK-A receptors.
CCK Binding (recognizes) of gastrin associated with cholecystokinin
1) Confidence 0.49 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.43
Cholecystokinin (CCK) is structurally closely related to gastrin and shares high affinity for CCK-B/gastrin receptors.
CCK Binding (affinity) of gastrin associated with cholecystokinin
2) Confidence 0.38 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.42
In contrast to gastrin, CCK also recognizes CCK-A receptors.
CCK Binding (recognizes) of gastrin associated with cholecystokinin
3) Confidence 0.38 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.43
Cholecystokinin (CCK) is structurally closely related to gastrin and shares high affinity for CCK-B/gastrin receptors.
Cholecystokinin Binding (affinity) of gastrin associated with cholecystokinin
4) Confidence 0.38 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.42
The purpose of this study were 1) to quantify the lower esophageal sphincter (LES) response to intravenous cholecystokinin (CCK) in both man and the opossum in vivo, 2) to characterize the interaction of CCK and gastrin on circular muscle of the LES, and 3) to determine the site of action of CCK on LES muscle.
CCK Binding (interaction) of gastrin in muscle associated with cholecystokinin
5) Confidence 0.34 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 165733 Disease Relevance 0 Pain Relevance 0.57
The purpose of this study were 1) to quantify the lower esophageal sphincter (LES) response to intravenous cholecystokinin (CCK) in both man and the opossum in vivo, 2) to characterize the interaction of CCK and gastrin on circular muscle of the LES, and 3) to determine the site of action of CCK on LES muscle.
CCK Binding (interaction) of gastrin in muscle associated with cholecystokinin
6) Confidence 0.33 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 165733 Disease Relevance 0 Pain Relevance 0.57
Although the majority of our patients received acid suppression therapy and therefore may have had increased serum gastrin levels, the cross-reactivity between gastrin and CCK is less than 2% [46] and is unlikely to contribute to the elevated CCK concentrations.
CCK Binding (reactivity) of gastrin associated with cholecystokinin
7) Confidence 0.15 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.41 Pain Relevance 0.24

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