INT115108

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.16
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
skin 2
mast cells 2
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 3 98.44 Very High Very High Very High
Pain 15 96.84 Very High Very High Very High
Inflammatory response 2 96.48 Very High Very High Very High
cytokine 34 77.32 Quite High
Acute pain 1 75.24 Quite High
pruritus 2 75.00 Quite High
Inflammation 22 74.24 Quite High
Angina 10 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 102 99.98 Very High Very High Very High
Death 60 99.92 Very High Very High Very High
Apoptosis 247 99.88 Very High Very High Very High
Hypothermia 13 99.84 Very High Very High Very High
Mycobacterial Infection 141 99.78 Very High Very High Very High
Eosinophilic Esophagitis 106 99.56 Very High Very High Very High
Cv General 4 Under Development 1 98.80 Very High Very High Very High
Cicatrix 7 98.32 Very High Very High Very High
Pruritus 10 97.20 Very High Very High Very High
Pain 11 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 24 weeks, a decrease in the number of mast cells and the enhanced expression of Fas antigen by lesional fibroblasts were observed.
Negative_regulation (decrease) of Gene_expression (expression) of Fas in mast cells
1) Confidence 0.57 Published 2003 Journal J Dermatolog Treat Section Abstract Doc Link 14660274 Disease Relevance 1.15 Pain Relevance 0.46
We also investigated the number of mast cells and Fas antigen expression in the lesional skin (one patient) before and after treatment.
Spec (investigated) Negative_regulation (number) of Gene_expression (expression) of Fas in skin
2) Confidence 0.42 Published 2003 Journal J Dermatolog Treat Section Abstract Doc Link 14660274 Disease Relevance 1.24 Pain Relevance 0.46
Mtb-infection reduces the cell surface expression of Fas receptors, resulting in the resistance of the host cells to Fas-ligand induce cell death[21].
Negative_regulation (reduces) of Gene_expression (expression) of Fas associated with mycobacterial infection, death and infection
3) Confidence 0.41 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 2.15 Pain Relevance 0
Faslpr/lpr and Bcl2l11+/?
Negative_regulation (/) of Gene_expression (/) of Fas
4) Confidence 0.41 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.53 Pain Relevance 0.04
We identified, in fact, two independent tumors, with different localization and sharing some common features, markers of a highly aggressive potential: loss of cell differentiation markers and cell cycle regulators, ability to avoid death by suppressing Fas antigen expression and important invasive capacity by down regulation of E-cadherin expression.
Negative_regulation (suppressing) of Gene_expression (expression) of Fas associated with cancer and death
5) Confidence 0.41 Published 2010 Journal Rom J Morphol Embryol Section Abstract Doc Link 20191142 Disease Relevance 0.97 Pain Relevance 0.08
One model was developed using RBC-FAs(FA), another with the 7 standard risk factors (SRF), and another using the FAs selected in the FA model combined with the standard risk factors (SRF+FA).
Negative_regulation (developed) of Gene_expression (using) of FAs
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.16 Pain Relevance 0
One model was developed using RBC-FAs(FA), another with the 7 standard risk factors (SRF), and another using the FAs selected in the FA model combined with the standard risk factors (SRF+FA).
Negative_regulation (developed) of Gene_expression (using) of FAs
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.17 Pain Relevance 0
Phanithi and colleagues have also demonstrated that mild hypothermia (33°C) reduced Fas expression in a rat model of reversible cerebral ischemia when compared to normothermic controls [22].
Negative_regulation (reduced) of Gene_expression (expression) of Fas associated with hypothermia, cv general 4 under development and ischemia
8) Confidence 0.29 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.89 Pain Relevance 0.05
Recent evidence suggests that cells are more sensitive to Fas-mediated apoptosis when levels of Fas expression increase [36].
Negative_regulation (levels) of Gene_expression (expression) of Fas associated with apoptosis
9) Confidence 0.15 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.99 Pain Relevance 0.15
Likewise, there was a 3-fold decrease in Fas expression levels in EoE subjects compared to the treated EoE subjects (p < 0.05) (Figure 1f).


Negative_regulation (decrease) of Gene_expression (expression) of Fas associated with eosinophilic esophagitis
10) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.91 Pain Relevance 0

General Comments

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