INT115130

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.95
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neutrophils 2
ovary 1
PDZK1IP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 116 99.80 Very High Very High Very High
antidepressant 13 99.34 Very High Very High Very High
fluoxetine 3 99.32 Very High Very High Very High
noradrenaline 1 98.72 Very High Very High Very High
Dopamine 1 98.36 Very High Very High Very High
Desipramine 18 97.88 Very High Very High Very High
Calcium channel 1 92.24 High High
monoamine 2 71.60 Quite High
Inflammation 62 66.00 Quite High
Osteoarthritis 20 47.04 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 116 99.80 Very High Very High Very High
Ataxia 1 82.24 Quite High
Cv General 4 Under Development 3 79.52 Quite High
Dyskinesias 1 77.92 Quite High
Epilepsy 2 75.00 Quite High
Bronchiolitis Obliterans 1 69.80 Quite High
Increased Venous Pressure Under Development 1 67.76 Quite High
Absence Epilepsy 1 66.88 Quite High
INFLAMMATION 60 66.00 Quite High
Reperfusion Injury 1 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although administration of dopamine and noradrenaline was started and the inhaled concentration of NO was increased, sPAP overwhelmed sABP after all.
Gene_expression (overwhelmed) of sPAP associated with dopamine and noradrenaline
1) Confidence 0.65 Published 2010 Journal Masui Section Abstract Doc Link 20169963 Disease Relevance 0.42 Pain Relevance 0.10
The effects of the antidepressant drugs clomipramine (CLOM), desipramine (DMI), tianeptine (TIAN) and of norfluoxetine (NORF, the active metabolite of fluoxetine), were investigated in CHO cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene to determine their actions on cyclic AMP-driven gene transcription.
Spec (investigated) Gene_expression (expressing) of SPAP associated with desipramine, antidepressant and fluoxetine
2) Confidence 0.35 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.36
After prolonged exposure (7-21 days) to a low concentration (200 nM) of the antidepressants, the enhanced E(max) values for SPAP production evident after 18 h were not maintained but CLOM and DMI induced a significant leftward shift in the isoprenaline EC50 after a 7-day period of treatment and this was sustained at the 21 day time point.
Gene_expression (production) of SPAP associated with desipramine and antidepressant
3) Confidence 0.30 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.51
The model comprised CHObeta2 SPAP cells; Chinese hamster ovary cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene with multiple cAMP response elements (CREs) in its promoter region.
Gene_expression (expressing) of SPAP in ovary
4) Confidence 0.24 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16036225 Disease Relevance 0 Pain Relevance 0.26
The predicted duplication of 39 amino acid residues near the subunit's N terminus results in the expression of a full-length, membrane-associated protein.
Gene_expression (expression) of membrane-associated protein
5) Confidence 0.07 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14660671 Disease Relevance 0.49 Pain Relevance 0.05
In contrast, SF neutrophils from patients with RA not only express the membrane-associated form of RANK-L but also express RANK and secrete OPG.
Gene_expression (express) of membrane-associated in neutrophils associated with rheumatoid arthritis
6) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.53 Pain Relevance 0.27
We observed the expression of the membrane-associated form of RANK-L in healthy blood neutrophils.
Gene_expression (expression) of membrane-associated in neutrophils
7) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.51 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox