INT115143

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAPK1, TFAM) DNA binding (MAPK1, TFAM) nucleus (MAPK1, TFAM)
nucleoplasm (MAPK1) Golgi apparatus (MAPK1) protein complex (MAPK1)
MAPK1 (Homo sapiens)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 94.32 High High
cytokine 35 85.28 High High
cINOD 1 79.28 Quite High
antagonist 2 37.36 Quite Low
Inflammation 30 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 98.64 Very High Very High Very High
Colon Cancer 1 91.20 High High
INFLAMMATION 32 77.84 Quite High
Thymoma 1 45.32 Quite Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that TGZ induces an early growth response transcription factor (EGR-1) by the ERK phosphorylation pathway rather than by the PPARgamma pathway (Baek, S.
ERK Positive_regulation (induces) of transcription factor
1) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.44 Pain Relevance 0.13
The transcription factor CREB can be activated by the calcium/calmodulin-dependent protein kinase IV (CaMKIV) [82] and by the p38 MAPK pathway by means of MK2 or MSK1/2 [40,83].
p38 MAPK Positive_regulation (activated) of transcription factor
2) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.10

General Comments

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