INT115143

Context Info Confidence 0.02 First Reported 2004 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.49 Pain Relevance 0.22

mitochondrion (MAPK1, TFAM) DNA binding (MAPK1, TFAM) nucleus (MAPK1, TFAM) nucleoplasm (MAPK1) Golgi apparatus (MAPK1) protein complex (MAPK1)

MAPK1 (Homo sapiens) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 94.32 cytokine 35 85.28 cINOD 1 79.28 antagonist 2 37.36 Inflammation 30 5.00 rheumatoid arthritis 4 5.00 Arthritis 3 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 4 98.64 Colon Cancer 1 91.20 INFLAMMATION 32 77.84 Thymoma 1 45.32 Autoimmune Disease 14 5.00 Disease 10 5.00 Hypersensitivity 7 5.00 Stress 6 5.00 Rheumatoid Arthritis 4 5.00 Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We previously reported that TGZ induces an early growth response transcription factor (EGR-1) by the ERK phosphorylation pathway rather than by the PPARgamma pathway (Baek, S.

ERK Positive_regulation (induces) of transcription factor

1) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.44 Pain Relevance 0.13

The transcription factor CREB can be activated by the calcium/calmodulin-dependent protein kinase IV (CaMKIV) [82] and by the p38 MAPK pathway by means of MK2 or MSK1/2 [40,83].

p38 MAPK Positive_regulation (activated) of transcription factor

2) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.05 Pain Relevance 0.10

General Comments

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