INT115146

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.43
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1, EGR1) DNA binding (MAPK1, EGR1) cytoplasm (MAPK1, EGR1)
nucleus (MAPK1, EGR1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
MAPK1 (Homo sapiens)
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 29 94.32 High High
cINOD 9 79.28 Quite High
Inflammation 2 71.28 Quite High
Pain 1 61.40 Quite High
antagonist 25 37.36 Quite Low
cytokine 1 25.00 Low Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 145 98.64 Very High Very High Very High
Death 30 94.48 High High
Colon Cancer 12 92.68 High High
Cancer 68 81.88 Quite High
INFLAMMATION 4 77.84 Quite High
Injury 2 74.36 Quite High
Reprotox - General 1 4 71.40 Quite High
Ulcers 1 69.80 Quite High
Pain 1 61.40 Quite High
Carcinoma 2 59.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that TGZ induces an early growth response transcription factor (EGR-1) by the ERK phosphorylation pathway rather than by the PPARgamma pathway (Baek, S.
ERK Positive_regulation (induces) of EGR-1
1) Confidence 0.13 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.44 Pain Relevance 0.13
Moreover, sulindac sulfide stimulated the nuclear translocation of the transcription factor EGR-1, which was also mediated by ERK1/2 signaling pathway.
ERK1/2 Positive_regulation (mediated) of EGR-1
2) Confidence 0.08 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.82 Pain Relevance 0.34
suggesting an ERK-dependent induction of EGR-1.
ERK-dependent Positive_regulation (induction) of EGR-1
3) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.18 Pain Relevance 0.11

General Comments

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