INT115186

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) aging (IL6) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
IL6 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 93.52 High High
Inflammation 54 50.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 1 85.96 High High
Coagulation Disorder 2 84.12 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 70.24 Quite High
Atherosclerosis 44 59.68 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Adhesions 7 16.40 Low Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 rapidly induced phosphorylation of STAT 3 in a dose- and time-dependent manner with a peak expression at 30 min.
IL-6 Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT 3
1) Confidence 0.19 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.28 Pain Relevance 0
In the same cell type neither IL-1beta-dependent SAPK activation nor IL-6-induced STAT3 phosphorylation is affected by the drug.
IL-6-induced Neg (neither) Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT3
2) Confidence 0.08 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48

General Comments

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