INT11519

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.96
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Coc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 29 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
Dismenorea 32 99.98 Very High Very High Very High
cva 12 93.32 High High
Intracerebroventricular 1 93.28 High High
Dopamine 3 92.96 High High
local anesthetic 2 92.40 High High
Nucleus accumbens 1 91.76 High High
corticosteroid 2 89.68 High High
opiate 2 88.00 High High
Disease Link Frequency Relevance Heat
Hemorrhage 238 100.00 Very High Very High Very High
Reprotox - General 1 178 99.98 Very High Very High Very High
Disorder Of Lipid Metabolism 12 99.12 Very High Very High Very High
Cv General 3 Under Development 4 93.32 High High
Cyst 2 89.60 High High
Vomiting 40 82.56 Quite High
Body Weight 52 82.48 Quite High
Headache 30 82.08 Quite High
Cardiovascular Disorder Under Development 1 81.92 Quite High
Weight Gain 12 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significantly greater proportion of women using NuvaRing perceived a decrease in duration of bleeding than those on the COC (p < 0.01).
Negative_regulation (decrease) of COC associated with hemorrhage
1) Confidence 0.50 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 1.65 Pain Relevance 0
There appears to be two diametrically opposed cardiovascular actions of Coc.
Negative_regulation (opposed) of Coc associated with cocaine
2) Confidence 0.41 Published 1992 Journal Toxicology Section Abstract Doc Link 1566279 Disease Relevance 0.23 Pain Relevance 0.32
Unfortunately, the influence of the lower EE exposure with NuvaRing on coagulation factors and lipid metabolism remains unknown, as no RCTs between NuvaRing and the COC on these important metabolic parameters have been published yet.
Negative_regulation (published) of COC
3) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 0.33 Pain Relevance 0.05
g EE per day) compared with that for a COC containing 30 ?
Negative_regulation (compared) of COC
4) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 0.38 Pain Relevance 0.08
After 1 year of treatment, moderate or severe PMS or dysmenorrhea decreased in both the NuvaRing and COC groups (DRSP/30EE) with no apparent differences between the treatments (Milsom et al 2006).
Negative_regulation (decreased) of COC associated with dismenorea
5) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 0.69 Pain Relevance 0.46
The aODN in mice almost completely blocked the stimulatory effects of AMPH and other releasers but was ineffective in reducing the central activity of COC.
Negative_regulation (reducing) of COC associated with cocaine
6) Confidence 0.33 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12700677 Disease Relevance 0.06 Pain Relevance 0.54
The disposition of both COC and MOR was unaffected by the presence of the other drug.
Neg (unaffected) Negative_regulation (unaffected) of COC associated with morphine and cocaine
7) Confidence 0.25 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578376 Disease Relevance 0 Pain Relevance 1.25
g EE COC.13 If escape ovulation occurs in these women, pregnancy may still be prevented due to effects on cervical mucus and endometrial histology.
Negative_regulation (prevented) of COC
8) Confidence 0.19 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990910 Disease Relevance 0.09 Pain Relevance 0
Apolipoprotein A-1 levels increased in NuvaRing group but decreased in COC group, and lipoprotein(a) decreased in both groups.
Negative_regulation (decreased) of COC associated with disorder of lipid metabolism
9) Confidence 0.19 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990910 Disease Relevance 0.54 Pain Relevance 0.04

General Comments

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