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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2004
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
Anatomy Link Frequency
colon 1
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 90.08 High High
cINOD 6 49.12 Quite Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nerve Sheath Neoplasms 22 92.08 High High
Apoptosis 37 90.88 High High
Watson Syndrome 19 36.52 Quite Low
Cancer 16 25.92 Quite Low
Reprotox - General 1 2 10.00 Low Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As this result suggests an effect at transcriptional level, we examined whether the drug interferes with the activation of nuclear factor (NF)-kappaB and STAT3 transcription factors and with SAPK signal transducing factor.
SAPK Spec (whether) Binding (interferes) of
1) Confidence 0.27 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.39
On the other hand, it was previously shown that the JNK-pathway is associated with the biological mechanism of action of the Sulindac metabolites in human colon cells [21].
JNK-pathway Binding (associated) of in colon
2) Confidence 0.11 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.84 Pain Relevance 0

General Comments

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