INT115193

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 11.37
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
cardiomyocytes 6
nucleus 4
fibroblasts 3
myocardium 2
granulocyte 2
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 392 99.98 Very High Very High Very High
ischemia 23 99.36 Very High Very High Very High
Paracetamol 9 93.52 High High
Inflammation 461 86.84 High High
addiction 15 80.08 Quite High
Analgesic 2 78.88 Quite High
fibrosis 28 78.04 Quite High
antagonist 52 77.80 Quite High
adenocard 9 72.40 Quite High
alcohol 12 69.64 Quite High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 7 100.00 Very High Very High Very High
Reprotox - General 1 4 99.80 Very High Very High Very High
Hepatitis 35 99.60 Very High Very High Very High
Cv Unclassified Under Development 11 99.36 Very High Very High Very High
Disease 152 98.52 Very High Very High Very High
Glioma 34 98.20 Very High Very High Very High
Fibrosis 32 98.16 Very High Very High Very High
Sarcoma 1 96.92 Very High Very High Very High
Glioblastoma 19 95.76 Very High Very High Very High
Anaplastic Astrocytoma 2 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although our previous work both in 48 h PO myocardium and in RGD-stimulated adult cardiomyocytes3, 4 demonstrates c-Src recruitment and activation, expression of DNSrc in cardiomyocytes in the 3D environment did not affect the RGD-stimulated STAT3 phosphorylation.
Neg (not) Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of STAT3 in cardiomyocytes
1) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Tyrosine kinases that mediate STAT3 phosphorylation include: (i) JAK kinases that function downstream of cytokines, (ii) other NTKs, such as c-Src and BMX, and (iii) growth factor receptor kinases, such as epidermal growth factor receptor.
Positive_regulation (mediate) of Phosphorylation (phosphorylation) of STAT3 associated with cytokine
2) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.11 Pain Relevance 0.08
PO also caused increased levels of phosphorylated STAT3 in both cytoplasmic and nuclear fractions.
Positive_regulation (caused) of Phosphorylation (phosphorylated) of STAT3
3) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.49 Pain Relevance 0
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Positive_regulation (required) of Phosphorylation (phosphorylation) of STAT3 in nucleus
4) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.19 Pain Relevance 0.08
These data suggest that c-Src kinase activity is not critical for STAT3 phosphorylation, however, it is possible that c-Src may function as an adaptor to recruit other NTKs for STAT3 phosphorylation.
Neg (not) Positive_regulation (critical) of Phosphorylation (phosphorylation) of STAT3
5) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Next to STAT3 phosphorylation, HCV induces ERK1/2 phosphorylation [27].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of STAT3 associated with hepatitis c virus infection
6) Confidence 0.55 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.67 Pain Relevance 0.06
The cellular responses after warm ischemia were preceded by the molecular activation of nuclear factor kappa B, upregulation of granulocyte colony-stimulating factor and IL-6 mRNA and phosphorylation of the downstream signaling and transcription factor Stat3 [59].
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Stat3 in granulocyte associated with ischemia
7) Confidence 0.49 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.63 Pain Relevance 0.27
, JAK2 is phosphorylated and initiates the phosphorylation of STAT3.
Positive_regulation (initiates) of Phosphorylation (phosphorylation) of STAT3
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
Subsequent activation of BMX can then mediate STAT3 phosphorylation.
Positive_regulation (mediate) of Phosphorylation (phosphorylation) of STAT3
9) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.16 Pain Relevance 0.03
We were then able to reproduce this activation in 3D collagen-embedded cardiomyocytes stimulated with RGD peptide.3, 4 Therefore, we utilized our 3D collagen model to demonstrate that integrin stimulation with RGD peptide causes STAT3 activation/phosphorylation and to characterize the responsible upstream NTK(s).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of STAT3 in cardiomyocytes
10) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Since STAT3 phosphorylation was observed in both the nucleus and MSK of 48 h PO myocardium, even while JAK2 was inactive, these findings strongly suggest that BMX-mediated STAT3 activation not only contributes to cytoskeletal remodeling but also to the transcriptional activation in the nucleus.
Positive_regulation (observed) of Phosphorylation (phosphorylation) of STAT3 in myocardium
11) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.16 Pain Relevance 0.03
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Positive_regulation (required) of Phosphorylation (phosphorylation) of STAT3 in nucleus
12) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.19 Pain Relevance 0.08
Furthermore, increased tyrosine phosphorylation of STAT3 (P-STAT3) at Tyr705 (indicating activation) was detected in all three (soluble, CSK, and MSK) fractions of pressure-overloaded RV, when compared to normally loaded LV subfractions (right panel), although it was higher in Triton X-100 soluble and insoluble MSK fractions when compared to CSK fraction.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of STAT3
13) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.05 Pain Relevance 0
Tyrosine phosphorylation of STAT3 by NTKs is critical for the activation of STAT3.6, 17 Moreover, this phosphorylation may help direct STAT3 to particular subcellular locations including endosomal compartments,18 cytoskeleton,8, 9 microtubules,10 and nucleus19 which influences its function.
Positive_regulation (critical) of Phosphorylation (phosphorylation) of STAT3
14) Confidence 0.46 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.49 Pain Relevance 0.08
In gliomas, cytokines, such as interleukin (IL)-6 (IL-6) [4,5] and epidermal growth factor [5], can cause subsequent phosphorylation and activation of STAT-3.
Positive_regulation (cause) of Phosphorylation (phosphorylation) of STAT-3 associated with glioma and cytokine
15) Confidence 0.46 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.86 Pain Relevance 0.05
In the same cell type neither IL-1beta-dependent SAPK activation nor IL-6-induced STAT3 phosphorylation is affected by the drug.
Neg (neither) Positive_regulation (activation) of Phosphorylation (phosphorylation) of STAT3
16) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.48
on the SC membrane, inducing the phosphorylation of STAT3 via GP130/JAK2 activation within the SC [17], [50], [55].
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of STAT3
17) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.22 Pain Relevance 0
PO also caused increased levels of phosphorylated STAT3 in both cytoplasmic and nuclear fractions.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of STAT3
18) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.49 Pain Relevance 0
These results indicate that the kinase function of c-Src does not contribute to STAT3 phosphorylation in PO myocardium in vivo or RGD-stimulated adult cardiomyocytes in in vitro.


Neg (not) Positive_regulation (contribute) of Phosphorylation (phosphorylation) of STAT3 in cardiomyocytes
19) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Indeed, cytokine stimulation of STAT3 phosphorylation is transient (~30 minutes).
Positive_regulation (stimulation) of Phosphorylation (phosphorylation) of STAT3 associated with cytokine
20) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.29 Pain Relevance 0.05

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